113525-87-4

Basic information

• Product Name: Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, methyl
• Synonyms: 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxyPropanoic acid methyl ester;3-tert-Butoxycarbonylamino-2-hydroxy-propionic acid methyl ester
• CAS NO: 113525-87-4
• Molecular Formula: C₉H₁₇NO₅
• Molecular Weight: 219.24
• Product Categories: N-BOC
• Mol File: 113525-87-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 349.2±32.0 °C(Predicted)
• Appearance: /
• Density: 1.148±0.06 g/cm3(Predicted)
• PKA: 11.83±0.46(Predicted)
• CAS DataBase Reference: Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, methyl(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, methyl(113525-87-4)
• EPA Substance Registry System: Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, methyl(113525-87-4)

Safety Data

• Hazardous Substances Data: 113525-87-4(Hazardous Substances Data)

Usage

General Description

Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-, methyl, also known as ibufenac, is a nonsteroidal anti-inflammatory drug (NSAID) that is used for its analgesic and anti-inflammatory properties. It is a derivative of propanoic acid and is structurally related to ibuprofen. Ibufenac works by inhibiting the production of prostaglandins, which are involved in the mediation of pain and inflammation. It is commonly used to treat conditions such as arthritis, menstrual pain, and acute injuries. However, it is not as widely used as ibuprofen due to its limited availability and potential for side effects.

Upstream product

• 113525-78-3 methyl N-Boc-2-oxazolidinone-5-carboxylate 
• 218916-64-4 3-tert-butyloxycarbonylamino-2(RS)-hydroxypropionic acid 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 147851-98-7 methyl 3-amino-2-hydroxypropionate 

Relevant articles and documents

NOVEL COMPOUNDS AND THEIR USE

The present invention provides compounds of the general formula (I) or a pharmaceutically acceptable prodrugs, salts and/or solvates thereof, wherein LHS is selected from the group consisting of LHSa and LHSb And wherein, the asterisk (*) marks the point of attachment; These compounds exhibit antibacterial activity against Gram-negative and Gram-positive bacteria, especially S. aureus, E. coli, K. pneumoniae and A. baumannii. Pharmaceutical compositions containing these compounds, therapeutic uses thereof and methods for manufacturing the same are also provided.

GLYCOSAMINOGLYCAN DERIVATIVE AND METHOD FOR PRODUCING SAME

The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.

MILD AND SELECTIVE RING-CLEAVAGE OF CYCLIC CARBAMATES TO AMINO ALCOHOLS

N-tert-Butoxycarbonylated 2-oxazolidinones and tetrahydro-2-oxazinones are smoothly cleaved to acyclic N-Boc-amino alcohols on treatment with catalytic amounts of cesium carbonate at room temperature.The versatility of the procedure is demonstrated in a facile cleavage of highly functionalized heterocycles without epimerization and β-elimination.