113525-95-4Relevant academic research and scientific papers
MILD AND SELECTIVE RING-CLEAVAGE OF CYCLIC CARBAMATES TO AMINO ALCOHOLS
Ishizuka, Tadao,Kunieda, Takehisa
, p. 4185 - 4188 (1987)
N-tert-Butoxycarbonylated 2-oxazolidinones and tetrahydro-2-oxazinones are smoothly cleaved to acyclic N-Boc-amino alcohols on treatment with catalytic amounts of cesium carbonate at room temperature.The versatility of the procedure is demonstrated in a facile cleavage of highly functionalized heterocycles without epimerization and β-elimination.
