1135280-28-2 Usage
Uses
KN-92 is a useful negative control for KN-93.
General Description
Useful as a negative control for KN-93 (Cat. No. 422708), a Ca2+/CaM kinase II inhibitor.
Biological Activity
kn-92 is the inactive analog of ca2+/calmodulin-dependent kinase ii (camkii) inhibitor kn-93. kn-92 has been often used as negative control for kn-93.kn-92 significantly reduced the sustained current amplitudes at the end of the 5-s depolarizing pulses of a wide range of kv channels such as kv1.5 and kv1.2 [1].
Biochem/physiol Actions
Cell permeable: yes
references
[1]. rezazadeh s, claydon tw, fedida d.kn-93(2-[n-(2-hydroxyethyl)]-n-(4-methoxybenzenesulfonyl)]amino-n-(4-chlorocinnamyl)-n-methylbenzylamine), a calcium/calmodulin-dependent protein kinase ii inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.j pharmacolexpther. 2006 apr;317(1):292-9.
Check Digit Verification of cas no
The CAS Registry Mumber 1135280-28-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,5,2,8 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1135280-28:
(9*1)+(8*1)+(7*3)+(6*5)+(5*2)+(4*8)+(3*0)+(2*2)+(1*8)=122
122 % 10 = 2
So 1135280-28-2 is a valid CAS Registry Number.
