1135280-28-2 Usage
Uses
Used in Research and Development:
KN92 phosphate is used as a negative control for [KN-93] for [ensuring the accuracy and reliability of experimental results in the study of Ca2+/CaM kinase II inhibition].
Used in Pharmaceutical Industry:
In the pharmaceutical industry, KN92 phosphate is used as a reference compound for [developing and testing new drugs targeting Ca2+/CaM kinase II pathways].
Used in Academic Research:
KN92 phosphate is used as a benchmark in [academic research] for [comparing the effects of different compounds on Ca2+/CaM kinase II activity and related cellular processes].
Used in Quality Control:
KN92 phosphate is utilized as a quality control measure in [the production and testing of Ca2+/CaM kinase II inhibitors] to ensure the consistency and effectiveness of these compounds.
Biological Activity
kn-92 is the inactive analog of ca2+/calmodulin-dependent kinase ii (camkii) inhibitor kn-93. kn-92 has been often used as negative control for kn-93.kn-92 significantly reduced the sustained current amplitudes at the end of the 5-s depolarizing pulses of a wide range of kv channels such as kv1.5 and kv1.2 [1].
Biochem/physiol Actions
Cell permeable: yes
references
[1]. rezazadeh s, claydon tw, fedida d.kn-93(2-[n-(2-hydroxyethyl)]-n-(4-methoxybenzenesulfonyl)]amino-n-(4-chlorocinnamyl)-n-methylbenzylamine), a calcium/calmodulin-dependent protein kinase ii inhibitor, is a direct extracellular blocker of voltage-gated potassium channels.j pharmacolexpther. 2006 apr;317(1):292-9.
Check Digit Verification of cas no
The CAS Registry Mumber 1135280-28-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,5,2,8 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1135280-28:
(9*1)+(8*1)+(7*3)+(6*5)+(5*2)+(4*8)+(3*0)+(2*2)+(1*8)=122
122 % 10 = 2
So 1135280-28-2 is a valid CAS Registry Number.
