1135282-95-9

Basic information

• Product Name: 4-[3-(tert-Butyl)-1,2,4-oxadiazol-5-yl]-benzenecarbonitrile
• Synonyms: 4-[3-(tert-Butyl)-1,2,4-oxadiazol-5-yl]-benzenecarbonitrile
• CAS NO: 1135282-95-9
• Molecular Formula: C13H13N3O
• Molecular Weight: 227.26182
• Mol File: 1135282-95-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 145-147°
• Appearance: /
• CAS DataBase Reference: 4-[3-(tert-Butyl)-1,2,4-oxadiazol-5-yl]-benzenecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[3-(tert-Butyl)-1,2,4-oxadiazol-5-yl]-benzenecarbonitrile(1135282-95-9)
• EPA Substance Registry System: 4-[3-(tert-Butyl)-1,2,4-oxadiazol-5-yl]-benzenecarbonitrile(1135282-95-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1135282-95-9(Hazardous Substances Data)

Upstream product

• 42956-75-2 N'-hydroxypivalimidamide 
• 619-65-8 4-cyanobenzoic Acid 

Relevant articles and documents

Novel bioactive 1,2,4-oxadiazole natural product analogs. Synthesis, structural analysis and potential antitumor activity

The synthesis of new 1,2,4-oxadiazoles derivatives is reported. The main target was 3-tert-butyl-5-[4-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl]-1,2,4-oxadiazole (5), which was synthesized starting from 1,2,4-oxadiazol nitrile 1 in three steps. The target molecule 5 was investigated for antitumor activities in vitro, towards a panel of 12 cell lines using a monolayer cell survival and proliferation assay. The structural assignments were corroborated in four cases by X-ray structure analysis. (Chemical Equation Presented).