1135312-05-8 Usage
General Description
(R)-2,2,2-trifluoro-1-(2'-fluorophenyl)ethanol is a chemical compound that belongs to the family of fluorinated alcohols. It is a colorless liquid with a molecular formula of C8H7F4O and a molecular weight of 192.14 g/mol. (R)-2,2,2-trifluoro-1-(2'-fluorophenyl)ethanol is widely used in the pharmaceutical and agrochemical industries as a key building block in organic synthesis. It is also used as a chiral auxiliary in asymmetric synthesis, as well as a ligand in metal-catalyzed reactions. Additionally, it has potential applications in the field of medicinal chemistry due to its unique structural and physicochemical properties. Overall, (R)-2,2,2-trifluoro-1-(2'-fluorophenyl)ethanol is a versatile compound with various industrial and research applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1135312-05-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,5,3,1 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1135312-05:
(9*1)+(8*1)+(7*3)+(6*5)+(5*3)+(4*1)+(3*2)+(2*0)+(1*5)=98
98 % 10 = 8
So 1135312-05-8 is a valid CAS Registry Number.
1135312-05-8Relevant articles and documents
Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands
Brüning, Fabian,Nagae, Haruki,K?ch, Daniel,Mashima, Kazushi,Togni, Antonio
supporting information, p. 10818 - 10822 (2019/07/31)
The asymmetric hydrogenation of 2,2,2-trifluoroacetophenones and aryl perfluoroalkyl ketones was developed using a unique, well-defined chloride-bridged dinuclear rhodium(III) complex bearing Josiphos-type diphosphine ligands. These complexes were prepared from [RhCl(cod)]2, Josiphos ligands, and hydrochloric acid. As catalyst precursors, they allow for the efficient and enantioselective synthesis (up to 99 % ee) of chiral secondary alcohols with perfluoroalkyl groups. This system does not require an activating base for the hydrogenation of 2,2,2-trifluoroacetophenones. Additionally, the enantioselective C=O hydrogenations of 2-phenyl-3-(haloacetyl)-indoles, a class of privileged structures in medicinal chemistry, is reported for the first time.
