1135346-97-2Relevant academic research and scientific papers
Studies toward the synthesis of (-)-zampanolide: Preparation of the macrocyclic core
Troast, Dawn M.,Yuan, Jiayi,Porco Jr., John A.
experimental part, p. 1701 - 1711 (2009/07/18)
Studies towards the synthesis of the macrocyclic core of (-)-zampanolide are reported. The synthetic approach features a one-pot reduction/vinylogous aldol reaction for construction of the C-15-C-20 fragment, an intramolecular silyl-modified Sakurai (ISMS) reaction for construction of the 2,6-cis-disubstituted exo-methylene pyran subunit, and use of an sp 2-sp3 Stille reaction for macrocyclization.
