1135347-75-9Relevant academic research and scientific papers
Synthesis and spectroscopic properties of furyl-phenyl-acrylates and naphthofurans and their interaction with ct-DNA
Starcevic, Kristina,Hranjec, Marijana,Caric, Dejana,Karminski-Zamola, Grace
experimental part, p. 975 - 983 (2009/09/25)
A series of novel substituted derivatives related to furyl-phenyl-acrylates and naphthofurans, was synthesized and characterized by UV/Vis and fluorescence spectroscopy. Acyclic compounds can undergo photochemical dehydrocyclization by visible light irradiation in order to obtain their cyclic derivatives. The interactions of the prepared compounds with calf thymus DNA was investigated by means of electronic absorption and fluorescence spectra. It is intriguing that addition of ct-DNA induced a fluorescence increase of acyclic derivatives, exactly the opposite of the strong fluorescence quenching observed for cyclic derivatives 10 and 12. Compound 11 showed decreasing fluorescence intensity for lower concentrations of ct-DNA, while increasing of fluorescence is observed for high excess of added ct-DNA.
