113541-01-8 Usage
Uses
Used in Biological Research:
[125I]-PAPA-XAC is used as a research tool for studying the binding of ligands to various receptors and enzymes, particularly focusing on the A3 adenosine receptor.
Used in Radioimmunoassays:
[125I]-PAPA-XAC is used as a tracer in radioimmunoassays to investigate the distribution and localization of A3 adenosine receptors in tissues and cells.
Used in Autoradiography:
[125I]-PAPA-XAC is used as a radioactive marker in autoradiography to visualize the presence and distribution of A3 adenosine receptors within biological samples.
Used in Understanding Physiological and Pathological Roles:
[125I]-PAPA-XAC is used as a diagnostic agent to help researchers comprehend the physiological and pathological roles of the A3 adenosine receptor in various biological processes.
Used in Pharmaceutical Development:
[125I]-PAPA-XAC is used as a lead compound in the development of new drugs targeting the A3 adenosine receptor, which may have therapeutic applications in treating certain diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 113541-01-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,5,4 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 113541-01:
(8*1)+(7*1)+(6*3)+(5*5)+(4*4)+(3*1)+(2*0)+(1*1)=78
78 % 10 = 8
So 113541-01-8 is a valid CAS Registry Number.
113541-01-8Relevant academic research and scientific papers
Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors
Jacobson,Barone,Kammula,Stiles
, p. 1043 - 1051 (2007/10/02)
Functionalized congeners derived from 1,3-dipropyl-8-phenylxanthine and from N6-phenyladenosine were derivatized to contain electrophilic groups (isothiocyanate, N-hydroxysuccinimide ester, maleimide, sulfonyl chloride, or α-haloacyl group) capable of reaction with nucleophiles on biopolymers. The goal was to inhibit chemically the A1 adenosine receptor by using reactive agonist and antagonist ligands. Some of the electrophilic derivatives were synthesized through acylation of amine-functionalized congeners using hetero- or homobifunctional reagents available for protein cross-linking. The affinity for A1 adenosine receptors was evaluated in competitive binding assays by using rat and bovine brain membranes. Several xanthine and adenosine thiourea derivatives prepared from 1,3- and 1,4-phenylene diisothiocyanate (DITC) were potent irreversible inhibitors of adenosine receptors. Derivatives of m-DITC, at concentrations between 10 and 500 nM, irreversibly eliminated binding at 90% of the A1-receptor sites. Receptor affinity of both xanthine and adenosine derivatives containing distal phenylthiourea substituents was diminished by electron-donating groups on the ring.
