1135439-04-1 Usage
General Description
1-[(6-chloro-3-pyridinyl)methyl]piperazine (SALTDATA: 2HCl) is a chemical compound that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a piperazine derivative that contains a pyridine ring and a chlorine atom. The compound is typically sold as a salt form with two molecules of hydrochloric acid (2HCl). It is known to have various biological activities, including antipsychotic, anxiolytic, and antiemetic effects, and it is also used as a starting material for the synthesis of other organic compounds. Additionally, it is important to handle this compound with care, as it may possess certain hazards and risks associated with its handling and use.
Check Digit Verification of cas no
The CAS Registry Mumber 1135439-04-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,5,4,3 and 9 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1135439-04:
(9*1)+(8*1)+(7*3)+(6*5)+(5*4)+(4*3)+(3*9)+(2*0)+(1*4)=131
131 % 10 = 1
So 1135439-04-1 is a valid CAS Registry Number.
1135439-04-1Relevant articles and documents
Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors
Dong, Ming-Xin,Lu, Lu,Li, Haitao,Wang, Xiaohua,Lu, Hong,Jiang, Shibo,Dai, Qiu-Yun
scheme or table, p. 3284 - 3286 (2012/06/18)
A series of novel 1,4-disubstituted piperidine/piperazine derivatives were designed, synthesized and evaluated for their in vitro activities against HIV-1 Bal (R5) infection in CEMX174 5.25M7 cells. A majority of these compounds showed potent anti-HIV-1 activities with IC50 at nanomolar levels. N-(4-Fluoro-benzyl)piperazine analog B07 hydrochloride exhibited potency against HIV-1 activity similar to that of TAK-220 hydrochloride, but it had much better water solubility (25 mg/ml in phosphate sodium buffer at 25 °C) and oral bioavailability (56%) than TAK-220 hydrochloride (a solubility of 2 mg/ml and oral bioavailability of 1.4%). These results suggest that B07 hydrochloride may serve as a better lead for the development of new anti-HIV-1 therapies or microbicides for treatment and prevent of HIV-1 infection.