1135610-85-3Relevant academic research and scientific papers
Discovery and structure-activity relationships of a novel series of benzopyran-based KATP openers for urge urinary incontinence
Zhang, Xuqing,Qiu, Yuhong,Li, Xiaojie,Bhattacharjee, Sheela,Woods, Morgan,Kraft, Patricia,Lundeen, Scott G.,Sui, Zhihua
body text, p. 855 - 866 (2009/09/06)
A novel series of benzopyran derivatives were synthesized and evaluated as KATP channel openers. Structure-activity relationships were investigated around 4-position of the benzopyran nucleus. Optimization of 4-substituent with some heterocyclic rings led to compound 13b bearing a benzo[d]isoxazol-3-one moiety as a potent and selective KATP channel opener in vitro. In two anesthetized rat models of myogenic bladder overactivity, compound 13b was found to inhibit spontaneous bladder contractions.
