1135616-49-7

Basic information

• Product Name: FMOC-ARG(ME,PBF)-OH
• Synonyms: FMOC-ARG(ME,PBF)-OH;N-ALPHA-FMOC-N-OMEGA-METHYL-N-OMEGA'-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE;N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino](methylimino)methyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-ornithine;FMoc-Arg(Pbf,Me)-OH;(S,Z)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-5-(3-Methyl-2-((2,2,4,6,7-pentaMethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoic acid;N-α-(9-Fluorenylmethoxycarbonyl)-N-ω-methyl-N-ω'-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine;Fmoc-Arg(Me,Pbf);Nα-Fmoc-Nω-methyl-Nω'-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine≥ 98% (HPLC)
• CAS NO: 1135616-49-7
• Molecular Formula: C35H42N4O7S
• Molecular Weight: 662.8
• Product Categories: Fmoc Amino Acids - Arg;amino acids
• Mol File: 1135616-49-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.33
• Storage Temp.: Store at 0°C
• PKA: 3.80±0.21(Predicted)
• CAS DataBase Reference: FMOC-ARG(ME,PBF)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-ARG(ME,PBF)-OH(1135616-49-7)
• EPA Substance Registry System: FMOC-ARG(ME,PBF)-OH(1135616-49-7)

Safety Data

• Hazardous Substances Data: 1135616-49-7(Hazardous Substances Data)

Usage

Description

FMOC-Arg (ME, PBF)-OH is a kind of protected form of arginine. Arginine is double-protected by butyloxycarbonyl (BOC) and 2, 2, 4, 6, 7-pentamethyldihydrobenzofuran-5-sulfonyl (PBF). It is a derivative for introducing mono-methyl-arginine during Fmoc SPPS. Coupling can be carried out using any standard activation method. PBF protecting group can be removed by TFA-mediated cleavage reaction. As a kind of protected amino acid, it is an important intermediate in various fields such as peptide synthesis, asymmetric synthesis, medicinal chemistry as well as polymer chemistry.

Chemical Properties

White powder

Uses

Fmoc-?Arg(Me,?pbf)?-?OH can be used as reactant/reagent in design, synthesis and structure-activity relationship of macrocyclic peptidomimetics that bind to WDR5 and block WDR5-MLL protein-protein interaction.

References

https://www.merckmillipore.com/CN/zh/product/Fmoc-Arg%28Me%2CPbf%29-OH,MDA_CHEM-852105?ReferrerURL=https%3A%2F%2Fguge6.firstguo.com%2F&bd=1 https://en.wikipedia.org/wiki/Peptide_synthesis Kim, Tae-il, et al. "Arginine-conjugated polypropylenimine dendrimer as a non-toxic and efficient gene delivery carrier." Biomaterials 28.11 (2007): 2061-2067.