Z-AEVD-FMK, also known as (5S,8S,11S,14S)-Methyl 14-(2-Fluoroacetyl)-11-isopropyl-8-(3-methoxy-3-oxopropyl)-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate, is a small molecule compound that functions as a caspase-10 inhibitor. It is characterized by its ability to bind to and inhibit the activity of caspase-10, a cysteine protease enzyme involved in the regulation of apoptosis, or programmed cell death.
1135688-47-9
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Basic information
- Product Name: Z-AEVD-FMK
- Synonyms: Z-ALA-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE;Z-ALA-GLU(OME)-VAL-ASP(OME)-FMK;Z-AE(OME)VD(OME)-FMK;Z-AE(OME)VD(OME)-FMK (FLUOROMETHYL);Z-AEVD-FMK;GROUP III CASPASE INHIBITOR I;CHZRBQFKZDGMTP-CDSYHYPYSA-N
- CAS NO:1135688-47-9
- Molecular Formula: C28H39FN4O10
- Molecular Weight: 610.63
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1135688-47-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 883.7±65.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.236±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 11.12±0.46(Predicted)
- CAS DataBase Reference: Z-AEVD-FMK(CAS DataBase Reference)
- NIST Chemistry Reference: Z-AEVD-FMK(1135688-47-9)
- EPA Substance Registry System: Z-AEVD-FMK(1135688-47-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1135688-47-9(Hazardous Substances Data)
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1135688-47-9 Usage
Uses
Used in Pharmaceutical Industry:Z-AEVD-FMK is used as a caspase-10 inhibitor for the study and treatment of various diseases and conditions where apoptosis plays a significant role. By inhibiting caspase-10, it can help researchers understand the role of this enzyme in cellular processes and potentially lead to the development of new therapeutic strategies for conditions such as cancer, neurodegenerative diseases, and autoimmune disorders.
Used in Research Applications:
In the field of research, Z-AEVD-FMK is used as a tool compound to investigate the molecular mechanisms underlying caspase-10-mediated apoptosis. It can be employed in various experimental setups, including cell culture studies, biochemical assays, and animal models, to explore the effects of caspase-10 inhibition on cell death pathways and cellular functions.
Used in Drug Development:
Z-AEVD-FMK may also be utilized in the development of novel therapeutic agents targeting caspase-10 or related enzymes. By understanding the structure-activity relationship and optimizing the compound's properties, researchers can potentially design more potent and selective inhibitors with improved pharmacokinetic and pharmacodynamic profiles for clinical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1135688-47-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,5,6,8 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.Calculate Digit Verification of CAS Registry Number 1135688-47:
(9*1)+(8*1)+(7*3)+(6*5)+(5*6)+(4*8)+(3*8)+(2*4)+(1*7)=169
169 % 10 = 9
So 1135688-47-9 is a valid CAS Registry Number.
1135688-47-9Upstream product
1135688-47-9Downstream Products
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Z-AEVD-FMK
