113576-64-0Relevant academic research and scientific papers
One-pot synthesis of 3,4-dihydro-2H-pyrido[1,2-α][1,3,5]triazin-2-one derivatives from N-(2′-pyridinyl)benzoylacetamide and nitrosobenzenes
Zaleska, Barbara,Trzewik, Bartosz,Stodolak, Ewa,Grochowski, Jacek,Serda, Pawel
, p. 2975 - 2979 (2004)
A convenient method leading to fused pyrido[1,2-α] [1,3,5]triazine-2-ones is described. It consists in a one-pot, two-step reaction of N-(2′-pyridinyl)benzoylacetamide with nitrosobenzenes. On the other hand, N-(2′-pyridinyl)acetoacetamide provides a C-2 condensation/addition product with nitrosobenzene. N-(2′-Pyridinyl)benzoylthioacetamide and N-(2′-pyridinyl)acetothioacetamide with nitrosobenzene undergo oxidative heterocyclisation leading to [1,2,4]thiadiazqlo[2,3-a]pyridine derivatives.
Synthesis, Reactions and Copper(II), Nickel(II), and Zinc(II) Complexes of N-(2-Pyridinyl)ketothioacetamides
Iliopoulos, Peter,Murray, Keith S.
, p. 433 - 444 (2007/10/02)
The synthesis and properties of two N-(2-pyridinyl)ketothioacetamide ligands, HL , and their complexes with nickel(II), copper(II), and zinc(II) are described.The ligands are potential O, S, N donors and are sulphur analogues of the O, O, N donor N-(2-pyridinyl)ketoacetamide ligands (1).The failur of certain thionation methods in the preparation of (4) from (1) is demonstrated.Ligands (4) show analogous spectroscopic properties to those of (1) and display thioketo-enol tautomerism in solution but readily oxidize to the 2H-pyridothiadiazoles (5).This redox activity is shown to be decreased at low temperatures and eliminated in the N-benzyl-N-(2-pyridinyl)ketothioacetamides (6), the N-benzylated derivatives of (4).Complexes of the type (M=NiII, CuII or ZnII) display spectral and magnetic properties typical of four-co-ordinate complexes in which co-ordination of the ligands is via the S,N donor sets with the O donor remaining unco-ordinated.E.s.r. spectra of a complex doped into and lattices show marked differences depending on the host, with the former being typical of planar coordination while the latter gives a rather unusual lineshape of distorted tetrahedral geometry.
