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113578-26-0

M-NISOLDIPINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 113578-26-0 Structure

  • Basic information

    1. Product Name: M-NISOLDIPINE
    2. Synonyms: M-NISOLDIPINE
    3. CAS NO:113578-26-0
    4. Molecular Formula: C20H24N2O6
    5. Molecular Weight: 388.418
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 113578-26-0.mol

  • Chemical Properties

    1. Melting Point: 122-124 °C
    2. Boiling Point: 505.8±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.205±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 2.69±0.70(Predicted)
    10. CAS DataBase Reference: M-NISOLDIPINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: M-NISOLDIPINE(113578-26-0)
    12. EPA Substance Registry System: M-NISOLDIPINE(113578-26-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 113578-26-0(Hazardous Substances Data)

113578-26-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 113578-26-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,5,7 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 113578-26:
(8*1)+(7*1)+(6*3)+(5*5)+(4*7)+(3*8)+(2*2)+(1*6)=120
120 % 10 = 0
So 113578-26-0 is a valid CAS Registry Number.

113578-26-0Downstream Products

113578-26-0Related news

Validated LC–MS–MS method for determination of M-NISOLDIPINE (cas 113578-26-0) polymorphs in rat plasma and its application to pharmacokinetic studies08/26/2019

A sensitive and specific liquid chromatography–tandem mass spectrometric (LC–MS–MS) method has been developed to determine m-nisoldipine in rat plasma. Sample was pretreated by a single-step protein precipitation with acetonitrile, in contrast to the liquid–liquid procedure frequently used f...detailed

Molecular and Cellular PharmacologyThe inhibitory effects of M-NISOLDIPINE (cas 113578-26-0) on the 5-hydroxytryptamine-induced proliferation of pulmonary artery smooth muscle cells via Ca2+ antagonism and antioxidant mechanisms08/25/2019

The excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) plays a critical role in the development of pulmonary arterial hypertension. Recent studies indicate that Ca2+ and reactive oxygen species are critically involved in the process of smooth muscle cell proliferation stimu...detailed

Simultaneous determination of M-NISOLDIPINE (cas 113578-26-0) and its three metabolites in rat plasma by liquid chromatography–mass spectrometry08/24/2019

A simple, sensitive and selective liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the simultaneous determination of m-nisoldipine and its three metabolites in rat plasma has been developed using nitrendipine as an internal standard (IS). Following liquid–liquid extraction...detailed

Thermodynamic stability analysis of M-NISOLDIPINE (cas 113578-26-0) polymorphs08/23/2019

Two polymorphic crystal forms of m-nisoldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester) were characterized by X-ray powder diffraction and IR-spectroscopy. The solubility of the two polymorphs in water at 25, 31, 37, 42, and 49 °C wa...detailed

Short communicationStudy of in vitro metabolism of M-NISOLDIPINE (cas 113578-26-0) in human liver microsomes and recombinant cytochrome P450 enzymes by liquid chromatography–mass spectrometry08/22/2019

This is a report about the investigation of the metabolic fate of m-nisoldipine in human liver microsomes and the recombinant cytochrome P450 enzymes by using LC–MS/MS. A sensitive and reliable LC–MS/MS method was developed to obtain a rapid and complete characterization of new metabolites and...detailed

Short communicationStudies on separation and pharmacokinetics of M-NISOLDIPINE (cas 113578-26-0) enantiomers in beagle dog plasma by LC/MS/MS08/21/2019

A rapid, sensitive and selective liquid chromatography–tandem mass spectrometric (LC/MS/MS) method was developed and validated for the separation and determination of m-nisoldipine enantiomers in beagle dog plasma. Samples were pretreated by a single-step protein precipitation with acetonitrile...detailed

Original articleOn the dimorphism and the pressure–temperature state diagram of racemic M-NISOLDIPINE (cas 113578-26-0), a dihydropyridine calcium ion antagonistSur le dimorphisme et le diagramme d’état pression-température de la M-NISOLDIPINE (cas 113578-26-0) racémique, une dihydroyridine antagoniste08/20/2019

SummaryThe pressure-temperature phase diagram of the dimorphism of racemic m-nisoldipine is constructed using temperatures and enthalpies of fusion of forms A and B. At ordinary pressure, the transition from form B to form A is found to occur around 192 K, which indicates that these polymorphs a...detailed

113578-26-0Relevant articles and documents

Structures and characterization of m-nisoldipine polymorphs

Yang, Caiqin,Zhang, Zhenwei,Zeng, Yanli,Wang, Jing,Wang, Yongli,Ma, Baoqing

experimental part, p. 2589 - 2594 (2012/07/14)

m-Nisoldipine, a dihydropyridine calcium ion antagonist, first synthesized in the School of Pharmaceutical Sciences, Hebei Medical University, exhibits two polymorphs A and B with different colors and morphologies. The single-crystal X-ray structure analysis reveals that polymorph A crystallizes in a monoclinic P21/c space group with a = 9.3045(2) A, b = 16.5991(5) A, c = 13.0018(3) A, β = 91.539(2)° and Z = 4, while B crystallizes in a triclinic space group of P1 with a = 7.4965(2) A, b = 11.4692(4) A, c = 12.3648(5) A, α = 68.093(2)°, β = 88.655(2)°, γ = 81.853(2)° and Z = 2. The m-nisoldipine molecules are connected through N-H...O hydrogen bonds between the carbonyl group and the amine group to form either a wavy chain for A or a linear chain for B. The two polymorphs show distinct physicochemical properties as characterized by IR, Raman, DSC and terahertz pulse spectroscopy. DFT theoretical calculations are also used to simulate the terahertz spectroscopy of the two polymorphs. The Royal Society of Chemistry 2012.

Crystal Structures and Pharmacologic Activities of 1,4-Dihydropyridine Calcium Channel Antagonists of the Isobutyl Methyl 2,6-Dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (Nisoldipine) Series

Fossheim, R.,Joslyn, A.,Solo, A. J.,Luchowski, E.,Rutledge, A.,Triggle, D. J.

, p. 301 - 305 (2007/10/02)

A series of isobutyl methyl 2,6-dimethyl-4-(X-substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylates (X= H, 2-NO2, 3-NO2, 3-CN, 3-MeO, 4-F, 2-CF3, 3-CF3, and 4-Cl) related to and including nisoldipine (X= 2-NO2) has been synthesized, their solid-state

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