113579-20-7Relevant academic research and scientific papers
Preparation of 2-phenyl-3-hydroxyquinoline-4(1H)-one-5-carboxamides as potential anticancer and fluorescence agents
Funk, Petr,Motyka, Kamil,D?ubák, Petr,Znojek, Pawel,Gurská, Soňa,Kusz, Joachim,McMaster, Claire,Hajdúch, Marián,Soural, Miroslav
, p. 48861 - 48867 (2015)
The synthesis of 3-hydroxyquinoline-4(1H)-one derivatives bearing substituted phenyl in position 2 and variously substituted carboxamide group in position 5 is described, with use of 3-nitrophthalic anhydride, α-haloketones and primary amines as the starting materials. The synthetic approach was inspired by the preparation of analogous derivatives reported previously. However, a different strategy had to be developed with the corresponding bis(phenacyl)-3-aminophthalates as the key intermediates. Synthesized hydroxyquinolinones, as well as their intermediates, were tested for their cytotoxic activity towards various cancer and non-malignant cell lines. The fluorescent properties of these compounds have also been evaluated. In both fields, interesting data were obtained and compared to isomeric compounds that have been studied in the past.
Comparable rates for cleavage of amide and ester bonds through nucleophilic attack by carboxylate anion and general acid catalysis by metal-bound water in a carboxypeptidase a model
Suh, Junghun,Park, Tae Hoon,Hwang, Byung Keun
, p. 5141 - 5146 (2007/10/02)
The kinetics of the Cu(II)- or Ni(II)-catalyzed deacylation of the methtyl ester (3) and the N,N-dimethyl amide (4) of 2-carboxy-6-[[2-(4-carboxymethyl)imidazolyl]azo]benzoate was measured in dimethyl sulfoxide containing 5% (v/v) water. Efficient catalys
Preparation of 7-oxaaporphine derivatives and evaluation of their dopaminergic activity
Banzatti,Carfagna,Commisso,Heidempergher,Pegrassi,Melloni
, p. 1466 - 1471 (2007/10/02)
A series of 7-oxaaporphine derivatives was prepared. The compounds were evaluated as dopaminergic agents. None of them showed either affinity for dopamine receptors or activity in vivo in the climbing behavior (mice) and turning behavior (6-hydroxydopamin
