113592-31-7Relevant academic research and scientific papers
Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2
Mores, Andreas,Matziari, Magdalini,Beau, Fabrice,Cuniasse, Philippe,Yiotakis, Athanasios,Dive, Vincent
, p. 2216 - 2226 (2008/12/20)
Angiotensin-Converting enzyme 2 (ACE2), a recently identified human homologue of angiotensin-converting enzyme, is a zinc metallocarboxypeptidase which may play a unique role in cardiovascular and renal function. Here we report the discovery of potent and
Phosphinic Acid Inhibitors of D-Alanyl-D-alanine Ligase
Parsons, William H.,Patchett, Arthur A.,Bull, Herbert G.,Schoen, William R.,Taub, David,et al.
, p. 1772 - 1778 (2007/10/02)
We report the synthesis of a series of phosphinic acid dipeptide analogues, NH2CH(R1)PO(OH)CH2CH(R2)CO2H, related to DAla-DAla.The best of these compounds are potent, essentially irreversible inhibitors of DAla-DAla ligase, and their
