113597-76-5

Upstream product

• 860182-92-9 2-(N-acetyl-sulfanilyl)-5-amino-benzoic acid ethyl ester 
• 794523-83-4 5-amino-2-sulfanilyl-benzoic acid ethyl ester 
• 34332-21-3 4,4'-diamino-2-methoxycarbonyl-diphenylsulfone 

Downstream Products

• 101513-28-4 2-cyano-4,4'-diamino-diphenylsulfone 
• 101513-56-8 5-amino-2-sulfanilyl-benzoic acid amide 
• 723236-50-8 5-Amino-2-(4-amino-benzenesulfonyl)-benzoyl chloride 

Relevant academic research and scientific papers

Preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones

Starting from 4,4'-diamino-diphenylsulfone (DDS) as a lead structure, new 2-substituted analogues as well as new 2-substituted 4-alkylamino-4'-amino diphenylsulfones have been designed and synthesized in different ways. This has led to compounds the inhibitory activity of which against 7,8-dihydropteroic acid synthase of plasmodia and mycobacteria is clearly superior to that of sulfadoxine and in most cases to that of DDS. Of special interest is 4'-amino-4-n-propylamino-2-methyl-diphenylsulfone. Together with inhibitors of 7,8-dihydrofolate reductase in vitro and in vivo it possesses a marked synergistic inhibitory activity against plasmodia. In contrast to DDS in doses up to 200 mg/kg p.o. (cat) no methemoglobin formation is observed. The compound has been selected for further studies.