1135993-41-7Relevant academic research and scientific papers
Synthesis of the neuroactive steroid antagonist 17-phenyl-5α-androst- 16-en-3α-ol by a palladium-catalysed coupling reaction
Bian, Xiaoqin,Li, Shuangshuang,Gang, Xin,Liu, Lanhai,Xie, Zengyang,Wang, Cunde
experimental part, p. 422 - 424 (2009/06/02)
The neurosteroid antagonist, 3α,5α-17-phenylandrost-16-en-3-ol, which selectively antagonises the GABA- modulatory and GABA-mimetic effects of 3α,5α-tetrahydroprogesterone and related 5α-pregnanes, was synthesised by a new route using palladium-catalysed coupling reaction as a key step. Commercially available 3α-hydroxy-5α- androstan-17-one gave the desired product in 4 steps with an overall yield of 79.5%.
