113602-60-1

Upstream product

• 872-31-1 3-Bromothiophene 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 
• 696-63-9 4-Methoxybenzenethiol 
• 1317-39-1 copper(I) oxide 
• 6165-69-1 Thien-3-ylboronic acid 
• 80472-59-9 S-(4-methoxyphenyl) (4-methylbenzene)thiosulfonate 
• 10486-61-0 3-thienyl iodide 
• 88-13-1 3-Thiophene carboxylic acid 

Downstream Products

• 128348-25-4 3-(4-Methoxyphenylsulfonyl)thiophene 
• 128348-42-5 4-(4-Hydroxyphenylsulfonyl)thiophene-2-sulfonamide 
• 119731-18-9 4-(4-Methoxyphenylsulfonyl)thiophene-2-sulfonamide 
• 128348-28-7 4-(4-Methoxyphenylsulfonyl)thiophene-2-sulfonyl Chloride 
• 128348-45-8 4-<<3-<(dimethylamino)methyl>-4-hydroxyphenyl>sulfonyl>thiophene-2-sulfonamide 
• 143509-67-5 4-<<3-<(diethylamino)methyl>-4-hydroxyphenyl>sulfonyl>thiophene-2-sulfonamide 
• 143509-69-7 4-<<3-<(N-isobutyl-N-methylamino)methyl>-4-hydroxyphenyl>sulfonyl>thiophene-2-sulfonamide 

Relevant academic research and scientific papers

Forging C?S(Se) Bonds by Nickel-catalyzed Decarbonylation of Carboxylic Acid and Cleavage of Aryl Dichalcogenides

A nickel-catalyzed decarbonylation of carboxylic acids cross-coupling protocol has been developed for the straightforward C?S(Se) bond formation. This reaction is promoted by a commercially-available, user-friendly, inexpensive, air and moisture-stable nickel precatalyst. Various carboxylic acids and a wide range of aryl dichalcogenide substrates were tolerated in this process which afforded products in good to excellent yields. In addition, the present reaction can be conducted on gram scale in good yield.

Electrochemically Promoted Nickel-Catalyzed Carbon-Sulfur Bond Formation

This work describes a nickel-catalyzed Ullmann-type thiolation of aryl iodidesunder mild electrochemical conditions. The simple undivided cell with graphene/nickel foam electrode setups offers excellent substrate tolerance, affording aryl and alkyl sulfides in good chemical yields. Furthermore, the mechanism for this electrochemical cross-coupling reaction has been investigated by cyclic voltammetry.

Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and: S -aryl thiosulfonates

Various diaryl sulfides, including heteroaryl- and nitrogen-containing sulfides, have been efficiently prepared by rhodium-catalyzed odorless deborylative arylthiolation of organoborons with S-aryl thiosulfonates. The ready availability of starting materials and further transformation of sulfides have rendered a diverse range of organosulfur compounds easily accessible.

4-Substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors

A series of 4-substituted thiophene- and furan-2-sulfonamides was prepared and was found to possess nanomolar-level potency for inhibition of human carbonic anhydrase II in vitro. Selected examples from this group were further evaluated for their potentia

N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof

The present invention is for compounds having the formula of N-1H-tetrazol-5-yl-2-thiophenecarboxamides, N-1H-tetrazol-5-yl-2-pyrrolecarboxamides, N-1H-tetrazol-5-yl-2-furancarboxamides or analogs of each of the carboxamides. The compounds are useful for the treatment of allergic or inflammatory conditions or diseases. Thus, pharmaceutical compositions and methods of use are also the invention. Processes of preparation for the compounds are also the invention.