113604-68-5

Usage

Structure

Tetrahydroindole with a 4-chlorophenyl group attached

Derivative

Indole

Usage

Building block in organic synthesis

Biological activity

Known for exhibiting biological activity

Potential applications

Anti-inflammatory and antioxidant properties, pharmaceuticals, precursor in the synthesis of other organic compounds.

Upstream product

• 57875-58-8 ethyl 2-(2-hydroxy-6-oxocyclohex-1-en-1-yl)acetate 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 113604-84-5 [2-(4-Chloro-phenylamino)-6-oxo-cyclohex-1-enyl]-acetic acid 

Relevant academic research and scientific papers

4-Keto-4,5,6,7-tetrahydrooxindoles and 1-Carboxymethylene-2-anilino-1-cyclohexen-6-ones with Potential Antiinflammatory Activity

1-Aryl-4-oxo-4,5,6,7-tetrahydroindoles (1-16) have been synthesised by the condensation of cyclohexane-1,3-dione-2-acetic esters with anilines.Hyrolysis of 1-16 affords the corresponding acids (17-32), bearing resemblance to the nonsteroidal antiinflammatory agent, diclofenac 38.Some members of both classes show antiinflammatory activity in the carragenin oedema test and analgesic activity in mouse writhing test, but are devoid of prostaglandin synthetase inhibiting property.Among these, 1-carboxymethylene-2-(4-trifluoromethylanilino)-1-cyclohexen-6-one (20) has marginal activity in the chronic adjuvant arthritis model of inflammation.