1136091-49-0Relevant academic research and scientific papers
A new convenient way to synthesize 1,3,4-thiadiazol-2-yl urea derivatives under microwave irradiation
Li, Kejian,Chen, Wenbin
, p. 621 - 629 (2008/12/22)
A simple and efficient method was developed for the synthesis of 1-(substituted)-3-(5-(substituted)-1,3,4-thiadiazol-2-yl) ureas from heterocyclic amino compounds and phenyl-5-(pyridine-3-yl)-1,3,4-thiadiazol-2- ylcarbamate(2) or phenyl-5-(trifluoro-methyl)-1,3,4-thiadiazol-2-ylcarbamate(5) under solvent conditions using microwave irradiation. The products were obtained in satisfactory yield as we expected. The reactions can be realized by conventional heating, but we find that the condition of microwave is better according to the reaction time. New J-(substituted)-3-(5-(substituted)-1,3,4- thiadiazol-2-yl) urea derivatives are reported. The products were characterized by 1H NMR, ESI-MS, and Elemental analysis. The crystal structure of compound 6h was determined by X-ray single crystal diffraction.
