113665-89-7

Basic information

• Product Name: 8,9-Z-AVERMECTINB1A
• Synonyms: 8,9-Z-AVERMECTINB1A
• CAS NO: 113665-89-7
• Molecular Formula: C₄₈H₇₂O₁₄
• Molecular Weight: 873.07688
• Mol File: 113665-89-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 940.9°Cat760mmHg
• Flash Point: 268.1°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 8,9-Z-AVERMECTINB1A(CAS DataBase Reference)
• NIST Chemistry Reference: 8,9-Z-AVERMECTINB1A(113665-89-7)
• EPA Substance Registry System: 8,9-Z-AVERMECTINB1A(113665-89-7)

Safety Data

• Hazardous Substances Data: 113665-89-7(Hazardous Substances Data)

Usage

Description

8,9-Z-Avermectin B1a, a member of the avermectin class of macrocyclic lactones, is a potent broad-spectrum antiparasitic agent. It is characterized by its ability to target the nervous system of parasites, causing paralysis and ultimately leading to their death. 8,9-Z-AVERMECTINB1A is known for its effectiveness, low toxicity to mammals, and its selective targeting of parasites, making it a valuable asset in the fight against a wide range of parasitic diseases.

Uses

Used in Veterinary Medicine:
8,9-Z-Avermectin B1a is used as an antiparasitic agent for the control and treatment of various parasitic infestations in livestock and domestic animals. Its broad-spectrum activity and low toxicity profile make it an ideal choice for maintaining the health of animals in various farming and breeding operations.
Used in Human Medicine Research:
8,9-Z-Avermectin B1a is being investigated for potential use in human medicine as a treatment for various parasitic infections. Its effectiveness against a wide range of parasites, coupled with its low toxicity to humans, positions it as a promising candidate for further research and development in the medical field.
Used in Parasite Control Programs:
In public health and disease control initiatives, 8,9-Z-Avermectin B1a is used as a key component in combating parasitic diseases that affect human populations. Its broad-spectrum activity and low toxicity make it suitable for large-scale distribution and administration in areas where parasitic infections are prevalent.
Used in Agricultural Applications:
8,9-Z-Avermectin B1a is also utilized in agriculture to protect crops from pests and parasites. Its ability to selectively target parasites without causing significant harm to non-target organisms makes it an environmentally friendly option for integrated pest management strategies.

InChI:InChI=1/C48H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,11,16,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25?,26-,28-,30?,31?,33+,34-,35?,36?,37?,38?,39?,40+,41?,42?,43+,44?,45+,47+,48+/m0/s1

Upstream product

• 106621-62-9 4'',5-bis-2-epiavermectin B_1a 
• 81924-42-7 4'',5-bisavermectin B_1a 
• 110415-68-4 Δ²-4(R)-avermectin B_1a 
• 65195-55-3 avermectin B₁a 
• 110319-01-2 4'',5,7-tris-Δ²-4(R)-avermectin B_1a 
• 65195-55-3 avermectin B_1a 
• 135431-95-7 C₆₀H₁₀₂O₁₅Si₂ 
• 135431-95-7 C₆₀H₁₀₂O₁₅Si₂ 
• 135431-96-8 C₆₁H₁₀₄O₁₅Si₂ 
• 135431-96-8 C₆₁H₁₀₄O₁₅Si₂ 
• 81924-42-7 avermectin B_1a bis(silyl ether) 
• 171028-71-0 Avermectin B_1a 
• 103002-45-5 C₆₃H₁₀₈O₁₄Si₃ 
• 103024-46-0 C₆₀H₁₀₀O₁₄Si₂ 

Downstream Products

• 65195-55-3 (8,9-Z)-avermectin B_1a 
• 65195-55-3 (10,11-Z)-avermectin B_1a 
• 65195-55-3 avermectin B₁a 
• 110415-68-4 Δ²-4(R)-avermectin B_1a 

Relevant articles and documents

Conversion of avermectin B1 to 19-epi-avermectin B1

Avermectin B1 (1) has been converted to 19-epi-avermectin B1 (2) in six steps. Analog 2 retains some bioactivity but is substantially less bioactive than 1.

Studies on the deconjugation-epimerization strategy en route to avermectin B(1a): Problems and solutions

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