113666-86-7

Basic information

• Product Name: (6S,7S)-7-<<(R)-2-(4-hydroxyphenyl)glycyl>amino>-8-oxo-3-(1-trans-3,3,3-trifluoropropenyl)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylic acid
• CAS NO: 113666-86-7
• Molecular Weight: 427.337
• Mol File: 113666-86-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6S,7S)-7-<<(R)-2-(4-hydroxyphenyl)glycyl>amino>-8-oxo-3-(1-trans-3,3,3-trifluoropropenyl)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (6S,7S)-7-<<(R)-2-(4-hydroxyphenyl)glycyl>amino>-8-oxo-3-(1-trans-3,3,3-trifluoropropenyl)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylic acid(113666-86-7)
• EPA Substance Registry System: (6S,7S)-7-<<(R)-2-(4-hydroxyphenyl)glycyl>amino>-8-oxo-3-(1-trans-3,3,3-trifluoropropenyl)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylic acid(113666-86-7)

Safety Data

• Hazardous Substances Data: 113666-86-7(Hazardous Substances Data)

Upstream product

• 113599-93-2 {(6S,7S)-2-Allyloxycarbonyl-7-[(R)-2-allyloxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-8-oxo-4-oxa-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl}-triphenyl-phosphonium; iodide 
• 113599-64-7 allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-tritylamino-1-azetidinyl>-3-oxo-4-chlorobutanoate 
• 113599-92-1 (6S,7S)-7-[(R)-2-Allyloxycarbonylamino-2-(4-hydroxy-phenyl)-acetylamino]-3-iodomethyl-8-oxo-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester 
• 113599-84-1 allyl (6S,7S)-7-<<(R)-N-<(allyloxy)carbonyl>-2-(4-hydroxyphenyl)glycyl>amino>-3-(chloromethyl)-8-oxo-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate 
• 113599-63-6 allyl 2-<(3S,4S)-4-<<(tert-butyldimethylsilyl)oxy>methyl>-2-oxo-3-(tritylamino)-1-azetidinyl>acetate 
• 113599-71-6 allyl 2-<(3S,4S)-4-(hydroxymethyl)-2-oxo-3-tritylamino-1-azetidinyl>-3-oxo-4-chlorobutanoate 
• 113599-78-3 allyl (6S,7S)-3-(chloromethyl)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate 
• 132931-98-7 (6S,7S)-7-Amino-3-chloromethyl-8-oxo-4-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester 
• 84792-41-6 (R)-N-<(allyloxy)carbonyl>-2-(4-hydroxyphenyl)glycine 
• 22818-40-2 D-4-hydroxyphenylglycine 

Relevant articles and documents

An Examination of O-2-Isocephems as Orally Absorbable Antibiotics

The synthesis and structure-activity relationships of a series of orally absorbed O-2-isocephems are described.These compounds possessed a D-amino substituent at the 7-position while the substituent at the 3-position was varied.Relative to the analogous cephems, the O-2-isocephems exhibited comparable to better activity against Gram-positive organisms.Against Gram-negative organisms, their activity was variable but did indicate a lower β-lactamase stability.Following oral administration, the O-2-isocephems generally exhibited longer half-lives but lower Cmax's and urinary recoveries.