113676-50-9Relevant articles and documents
ACID LABILE SURFACTANTS
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Paragraph 0069; 0073-0075, (2019/09/06)
This invention relates to an acid labile surfactant. In particular, the surfactants of the present invention include a dioxolane or dioxane functional group which enables the surfactant to hydrolyze in an acidic environment. Surfactants of this type can be utilized to enhance protein solubilization/enzyme digestion. Following hydrolysis to destroy the surfactant (which may chromatographic issues), there are generally two components formed—a hydrophilic one, and a hydrophobic one. By altering the chemistry of the hydrolysable linker, the polarity of the hydrophobic residue can be altered, allowing it to be solubilized by significantly less organic solvent, and to minimize the potential loss of peptide material and to expand the chromatographic conditions that can be utilized.
A comparative study of the liquid-crystalline behavior of three homologous series of 1,2-propanediol derivatives
Doren, Henk A. van,Geest, Ralph van der,Kellogg, Richard M.,Wynberg, Hans
, p. 197 - 203 (2007/10/02)
Homologous series (R = n-hexyl to n-tetradecyl) of 3-(alkylamino)-, 3-(alkylthio)- and 3-alkoxy-1,2-propanediols have been synthesized and their thermal behavior studied by thermomicroscopy and differential-scanning calorimetry.The occurence of liquid-crystalline behavior was found to be strongly dependent on both the alkyl-chain length and the hetero-atom that links the alkyl chain to the 1,2-propanediol moiety. No thermotropic liquid-crystalline behavior could be observed for 3-alkoxy-1,2-propanediols; 3-(heptylamino)- through 3-(nonylamino)-1,2-propanediol exhibit a transient smectic A phase on supercooling of the isotropic liquid, whereas 3-(hexylthio)-1,2-propanediol through 3-(nonylthio)-1,2-propanediol form smectic phases that are quite stable.Although the thermal behavior in the pure form differs considerably, all three classes of compounds are capable of lyotropic mesophase formation in the presence of water.