113681-11-1

Basic information

• Product Name: 3-(hydroxymethyl)cyclopentane
• Synonyms: 3-(hydroxymethyl)cyclopentane;3-(Hydroxymethyl)cyclopentanone - 90%+;Cyclopentanone,3-(hydroxyMethyl)-, (3S)-;(S)-3-(HydroxyMethyl)cyclopentanone
• CAS NO: 113681-11-1
• Molecular Formula: C6H12O
• Molecular Weight: 100
• Mol File: 113681-11-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 221.8±13.0 °C(Predicted)
• Appearance: /
• Density: 1.099±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.71±0.10(Predicted)
• CAS DataBase Reference: 3-(hydroxymethyl)cyclopentane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(hydroxymethyl)cyclopentane(113681-11-1)
• EPA Substance Registry System: 3-(hydroxymethyl)cyclopentane(113681-11-1)

Safety Data

• Hazardous Substances Data: 113681-11-1(Hazardous Substances Data)

Usage

Uses

3-(Hydroxymethyl)cyclopentanone is a reactant in the synthesis of D- and L-?Carbocyclic Nucleosides.

Upstream product

• 54673-14-2 [(ethoxymethoxy)methyl]benzene 
• 27490-33-1 tri-n-butylstannylmethanol 
• 93366-49-5 (+)-(R)-2-(p-tolylsulfinyl)cyclopent-2-enone 
• 220076-93-7 (2R,3R,R_S)-3-(hydroxymethyl)-2-[(2,4,6-trimethylphenyl)sulfinyl]-1-cyclopentanone 
• 220076-96-0 (2R,3R,R_S)-3-(hydroxymethyl)-2-[(2,4,6-triisopropylphenyl)sulfinyl]-1-cyclopentanone 
• 151951-76-7 (S)-2-[(2,4,6-triisopropylphenyl)sulfinyl]-2-cyclopentenone 
• 1322546-82-6 C₁₈H₂₈O₄SSi 
• 1322546-81-5 C₁₈H₃₀O₄SSi 
• 1322546-76-8 C₁₂H₁₄O₃S 
• 1322546-74-6 1-benzenesulfonyl-cyclopent-3-enecarboxylic ethyl ester 
• 140840-85-3 3-(((tert-butyldimethylsilyl)oxy)methyl)cyclopent-2-en-1-one 
• 1322546-79-1 tert-butyl(dimethyl){[1-(phenylsulfonyl)cyclopent-3-en-1-yl]methoxy}silane 
• 1071906-18-7 (S)-3-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopentanone 
• 196303-23-8 (3aS,4S,7R,7aR)-3-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-2-trimethylsilanyl-3a,4,7,7a-tetrahydro-4,7-methano-inden-1-one 

Relevant articles and documents

Synthesis of (3S)-(tert-butyldimethylsilyloxy)methylcyclopentan-1-one as a key intermediate of sphingosine 1-phosphate-1 receptor agonists

Herein we report the asymmetric synthesis of (3S)-(tert- butyldimethylsilyloxy)methylcyclopentan-1-one (S)-3 as a practical chiral synthon for a wide range of pharmaceutical and/or natural products, using Lipshutz's asymmetric copper-catalyzed conjugate reduction. This method makes it feasible to prepare a conformationally constrained cyclopentane analogue 12, which is one of the key intermediates for the synthesis of novel sphingosine 1-phosphate-1 receptor agonists.

Photo-induced intermolecular radical β-addition to chiral α- (arylsulfinyl) enones

The reactions of α-(arylsulfinyl) enones with alkyl radicals having a hydroxy or acetal group were examined under photo-irradiation in the presence of benzophenone. High diastereoselectivity was observed in the photo-induced radical reaction of 2-(arylsulfinyl)-2-cyclopentenones having a bulky aryl group, such as the 2,4,6-triisopropylphenyl or 2,4, 6-trimethylphenyl group. The photo-induced reaction of 3-[(2,4,6-triisopropylphenyl)sulfinyl]-3- pentene-2-one in 1,3-dioxolane also gave a single diastereomer of the 1,3- dioxolan-2-yl adduct.

ASYMMETRIC CONJUGATE ADDITIONS OF AN HYDROXYMETHYL CARBANION EQUIVALENT. SYNTHESIS OF (+)-A FACTOR

An effective procedure is presented for generation of Ph2CH2OCH2Li via tin -> lithium exchange and for conjugate addition of this HOCH2- equivalent to some homochiral cycloalkenone and butenolide sulfoxides.