113681-61-1Relevant articles and documents
Methylenomycin B: A New Synthesis from a β-Ketophosphonate
Mikolajczyk, Marian,Balczewski, Piotr
, p. 659 - 661 (2007/10/02)
Methylenomycin B (1) was prepared from diethyl 2-oxopropanephosphonate (5) in four steps in 26percent yield.The key steps in this synthesis include the Wittig-Horner reaction of 5 with methylthioethanal (7) followed by the 1,4-addition of a propionyl anion equivalent to the α-enone 4 formed affording 4-(methylthiomethyl)-hepta-2,5-dione (3) which is an acyclic precursor of the title antibiotic.