113697-97-5

Basic information

• Product Name: 4(1H)-Pyrimidinone, 2-amino-5-nitro-6-[(2-oxo-4-phenylbutyl)amino]-
• CAS NO: 113697-97-5
• Molecular Formula: C14H15N5O4
• Molecular Weight: 317.304
• Mol File: 113697-97-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4(1H)-Pyrimidinone, 2-amino-5-nitro-6-[(2-oxo-4-phenylbutyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 2-amino-5-nitro-6-[(2-oxo-4-phenylbutyl)amino]-(113697-97-5)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 2-amino-5-nitro-6-[(2-oxo-4-phenylbutyl)amino]-(113697-97-5)

Safety Data

• Hazardous Substances Data: 113697-97-5(Hazardous Substances Data)

Upstream product

• 31419-53-1 1-amino-4-phenyl-2-butan-one hydrochloride 
• 1007-99-4 2-amino-6-chloro-5-nitro-3H-pyrimidine-4-one 
• 501-52-0 3-Phenylpropionic acid 
• 645-45-4 hydrocinnamic acid chloride 
• 113697-86-2 5-Phenethyl-oxazole-4-carboxylic acid ethyl ester 

Downstream Products

• 109902-01-4 6-phenethyl-5,6,7,8-tetrahydropterin hydrochloride 

Relevant articles and documents

Lipophilic 5,6,7,8-tetrahydropterin substrates for phenylalanine hydroxylase (monkey brain), tryptophan hydroxylase (rat brain) and tyrosine hydroxylase (rat brain)

A high yielding unambiguous synthesis of (+/-)-6-alkyl-5,6,7,8-tetrahydropterin 5a-f hydrochlorides starting from ethyl α-isocyanoacetate 1 and the respective alkanoic anhydrides or alkanoyl chlorides in four steps is described.All the six pterins 5a-f that have been synthesised are substrates for mammalian phenylalanine, tryptophan and tyrosine hydroxylases and their activities have been compared with those of natural 6R-tetrahydrobiopterin under similar conditions.The data allowed the choice of 6-n-propyl-5,6,7,8-tetrahydropterin 5c for further studies as a candidate for tetrahydrobiopterin drug therapy.Keywords: (+/-)-6-alkyltetrahydropterinsydroxylase / tryptophan hydroxylase / tyrosine hydroxylase