1137-98-0Relevant academic research and scientific papers
Palladium-catalyzed sequential C-N/C-O bond formations: Synthesis of oxazole derivatives from amides and ketones
Zheng, Meifang,Huang, Liangbin,Huang, Huawen,Li, Xianwei,Wu, Wanqing,Jiang, Huanfeng
, p. 5906 - 5909 (2014)
A highly efficient method for the synthesis of oxazole derivatives from simple amides and ketones has been established via a Pd(II)-catalyzed sp2 C-H activation pathway in one step. The reaction is supposed to proceed through a C-N bond formation followed by a C-O bond formation closing the ring. Because of the simple and readily available starting materials, easy operation, and high bioactivity of oxazoles, this strategy can be broadly applied to medical chemistry.
Copper-catalyzed oxidative cyclization of arylamides and ?2-diketones: New synthesis of 2,4,5-trisubstituted oxazoles
Bai, Yang,Chen, Wen,Chen, Ya,Huang, Huawen,Xiao, Fuhong,Deng, Guo-Jun
, p. 8002 - 8005 (2015/02/19)
A novel copper catalyzed approach to oxazoles via enamide intermediates was developed from benzamides and ?2-diketones. The successive condensation and cyclization reactions afforded various 2,4,5-trisubstituted oxazoles in good yields.
