1137109-21-7 Usage
Description
alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol), also known as Mal-amido-PEG6-NHS, is a heterobifunctional crosslinker with an ethylene oxide spacer that is used for linking amineto sulfhydryl-containing compounds or biomolecules. It contains a maleimide group that reacts with sulfhydryls and a succinimidyl ester group that reacts with amines. The hydrophilic PEG spacer increases solubility in aqueous media, and the NHS ester can be used to label primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group forms a covalent bond with a thiol group, enabling the connection of biomolecules with a thiol.
Uses
Used in Bioconjugation:
alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) is used as a crosslinking agent for bioconjugation, enabling the covalent attachment of amine-containing molecules to thiol-containing molecules. This is useful for the formation of stable conjugates between proteins, peptides, and other biomolecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) is used as a drug delivery agent to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG spacer and maleimide group allow for the attachment of drugs to targeting molecules, such as antibodies or peptides, to enhance their delivery to specific cells or tissues.
Used in Diagnostic Imaging:
In the field of diagnostic imaging, alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) is used as a contrast agent for various imaging modalities, such as magnetic resonance imaging (MRI) and fluorescence imaging. The PEG spacer and maleimide group can be used to attach imaging agents to targeting molecules, improving their specificity and sensitivity for detecting diseases or monitoring biological processes.
Used in Biosensors:
In the development of biosensors, alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) is used as a functional component to immobilize enzymes, antibodies, or other recognition elements onto sensor surfaces. The maleimide group allows for the covalent attachment of these biomolecules, while the PEG spacer provides steric stabilization and reduces non-specific interactions, improving the performance and reliability of the biosensors.
Check Digit Verification of cas no
The CAS Registry Mumber 1137109-21-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,7,1,0 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1137109-21:
(9*1)+(8*1)+(7*3)+(6*7)+(5*1)+(4*0)+(3*9)+(2*2)+(1*1)=117
117 % 10 = 7
So 1137109-21-7 is a valid CAS Registry Number.
