113724-48-4Relevant articles and documents
Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones
Zhang, Lin,Zhang, Ling,Chen, Qian,Li, Linlin,Jiang, Jian,Sun, Hao,Zhao, Chong,Yang, Yuanyong,Li, Chun
supporting information, p. 415 - 419 (2022/01/12)
Most ligands applied for asymmetric hydrogenation are synthesized via multistep reactions with expensive chemical reagents. Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands have been developed in two steps. By combining [Ir(COD)Cl]2, 39 ketones including aromatic, heteroaryl, and alkyl ketones have been hydrogenated, all affording valuable chiral alcohols with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, and DFT, and an activating model involving trihydride was verified.
Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols
Hu, Xile,Zhang, Zhikun
supporting information, p. 22833 - 22838 (2021/09/09)
Deracemization of racemic chiral compounds is an attractive approach in asymmetric synthesis, but its development has been hindered by energetic and kinetic challenges. Here we describe a catalytic deracemization method for secondary benzylic alcohols which are important synthetic intermediates and end products for many industries. Driven by visible light only, this method is based on sequential photochemical dehydrogenation followed by enantioselective thermal hydrogenation. The combination of a heterogeneous dehydrogenation photocatalyst and a chiral molecular hydrogenation catalyst is essential to ensure two distinct pathways for the forward and reverse reactions. These reactions convert a large number of racemic aryl alkyl alcohols into their enantiomerically enriched forms in good yields and enantioselectivities.
Ferrocene derivative metal organic complex as well as preparation method and application thereof
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Paragraph 0147-0157, (2021/12/07)
The invention relates to the technical field of organic synthesis, in particular to a ferrocene derivative metal organic complex and a preparation method and application thereof. The ferrocene derivative metal organic complex disclosed by the invention is shown I, contains a pincerlike ligand in the structure, and therefore has high stability and long service life. , The ferrocene derivative type metal organic complex has high catalytic activity, and only 0.001 μM % - 0.01 μM % is used, so that the chiral compound can be efficiently and rapidly prepared. The ferrocene derivative metal organic complex central metal is ruthenium, the economic cost is low, and the method has the prospect of industrial popularization.