113732-62-0 Usage
General Description
2-bromo-1-(2,5-dimethyl-4-oxazolyl) is a chemical compound with the molecular formula C6H6BrNO and a molecular weight of 191.02 g/mol. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound is classified as a brominated oxazole derivative and is known for its high reactivity and versatility in chemical reactions. It is commonly used in organic synthesis and medicinal chemistry as a building block for the creation of more complex molecules. Additionally, 2-bromo-1-(2,5-dimethyl-4-oxazolyl) is known for its potential biological activities, and research has shown its potential as an anti-cancer and anti-inflammatory agent. Overall, this compound is of significant interest to the pharmaceutical and chemical industries due to its diverse applications and potential therapeutic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 113732-62-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,7,3 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 113732-62:
(8*1)+(7*1)+(6*3)+(5*7)+(4*3)+(3*2)+(2*6)+(1*2)=100
100 % 10 = 0
So 113732-62-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H8BrNO2/c1-4-7(6(10)3-8)9-5(2)11-4/h3H2,1-2H3
113732-62-0Relevant articles and documents
Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents
Sohda,Mizuno,Momose,Ikeda,Fujita,Meguro
, p. 2617 - 2626 (2007/10/02)
In the course of further chemical modification of the novel antidiabetic pioglitazone (AD-4833, U-72, 107), a series of 5-[4-(2- or 4- azolylalkoxy)benzyl- or -benzylidene]-2,4-thiazolidinediones was prepared and evaluated for hypoglycemic and hypolipidemic activities in insulin-resistant, genetically obese, and diabetic KKA(y) mice. Replacement of the 2-pyridyl moiety of pioglitazone by a 2- or 4-oxazolyl or a 2- or 4-thiazolyl moiety greatly enhanced in vivo potency. The corresponding 5-benzylidene-type compounds, in which a methine was used as a linker between the benzene ring and the thiazolidinedione ring, also had potent biological activity. Among the compounds synthesized, 5-[4-[2-(5-methyl-2-phenyl-4- oxazolyl)ethoxy]benzyl]-2,4-thiazolidinedione (18) exhibited the most potent activity, more than 100 times that of pioglitazone. The synthesis and structure-activity relationships for this novel series of derivatives are detailed.