113741-01-8

Basic information

• Product Name: 2-(2-METHYL-IMIDAZOL-1-YL)-ETHYLAMINE 2HCL
• Synonyms: [2-(2-METHYL-1H-IMIDAZOL-1-YL)ETHYL]AMINE DIHYDROCHLORIDE;2-(2-METHYLIMIDAZOLYL)ETHYLAMINE DIHYDROCHLORIDE;2-(2-METHYL-IMIDAZOL-1-YL)-ETHYLAMINE 2HCL;2-METHYL-1H-IMIDAZOLE-1-ETHYLAMINE;1-(2-Aminoethyl)-2-methyl-1H-imidazole;2-(2-Methyl-1H-imidazole-1-yl)ethylamine;2-(2-Methyl-1H-iMidazol-1-yl)ethanaMine hydrochloride;2-(2-Methyl-1H-iMidazol-1-yl)ethanaMine dihydrochloride
• CAS NO: 113741-01-8
• Molecular Formula: C6H13Cl2N3
• Molecular Weight: 198.09
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Imidazoles
• Mol File: 113741-01-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 116-120 °C
• Boiling Point: 273.598 °C at 760 mmHg
• Flash Point: 119.268 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0.00568mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.42±0.10(Predicted)
• CAS DataBase Reference: 2-(2-METHYL-IMIDAZOL-1-YL)-ETHYLAMINE 2HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-METHYL-IMIDAZOL-1-YL)-ETHYLAMINE 2HCL(113741-01-8)
• EPA Substance Registry System: 2-(2-METHYL-IMIDAZOL-1-YL)-ETHYLAMINE 2HCL(113741-01-8)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 113741-01-8(Hazardous Substances Data)

Usage

General Description

2-(2-METHYL-IMIDAZOL-1-YL)-ETHYLAMINE 2HCL, also known as 2-methylimidazole ethylamine hydrochloride, is a synthetic chemical compound with the formula C7H12Cl2N4. It is typically available as a white crystalline powder and has a molar mass of 225.11 g/mol. It belongs to the class of organic compounds known as imidazoles, which contain an imidazole ring, a five-membered ring with two non-adjacent nitrogen atoms. Imidazoles are commonly used in a wide range of applications, from pharmaceuticals and agrochemicals to dyes and pigments. Although toxicology and safety data on this individual compound may be limited, many imidazoles can exhibit harmful effects if inhaled or ingested and can be irritating to skin and eyes.

InChI:InChI=1/C6H11N3/c1-6-8-3-5-9(6)4-2-7/h3,5H,2,4,7H2,1H3

Upstream product

• 693-98-1 2-methylimidazole 
• 689-98-5 chloroethylamine 
• 870-24-6 2-chloroethanamine hydrochloride 
• 858512-76-2 2-[2-(2-methylimidazol-1-yl)ethyl]isoindole-1,3-dione 

Relevant articles and documents

(2-aminoethyl)-N hydrofluorination compd. manufacturing method

PROBLEM TO BE SOLVED: To provide a method for preparing an N-(2-aminoethyl)azole compound, which is a preparation method offering short reaction time, high purification efficiency of a final product, high production efficiency and high safety because a reaction solution undergoes no heat generation or rise of liquid level caused by bubbling. SOLUTION: The method for preparing the N-(2-aminoethyl)azole compound comprises reacting an azole-based compound (A) and an ethylamine derivative (B) having a leaving group at position 2 in the presence of a base (C) in a solvent (D) so as to prepare the N-(2-aminoethyl)azole compound. Here, the ethylamine derivative (B) having the leaving group at position 2 is fed to the reaction system in portions while the reaction system is maintained at 50-200°C. COPYRIGHT: (C)2010,JPOandINPIT

Benzoxazole carboxamides for treating CINV and IBS-D

Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D.