113759-19-6

Basic information

• Product Name: 4-(1-(2-fluoro-4-biphenyl)ethyl)-2-methylaminothiazole
• Synonyms: 4-(1-(2-fluoro-4-biphenyl)ethyl)-2-methylaminothiazole;4-[1-(2-Fluoro-1,1'-biphenyl-4-yl)ethyl]-2-(methylamino)thiazole;Flomatizole;SM-8849
• CAS NO: 113759-19-6
• Molecular Formula: C₁₈H₁₇FN₂S
• Molecular Weight: 312.4
• Mol File: 113759-19-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 433.3°C at 760 mmHg
• Flash Point: 215.9°C
• Appearance: /
• Density: 1.212g/cm³
• Vapor Pressure: 1.03E-07mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 4-(1-(2-fluoro-4-biphenyl)ethyl)-2-methylaminothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-(2-fluoro-4-biphenyl)ethyl)-2-methylaminothiazole(113759-19-6)
• EPA Substance Registry System: 4-(1-(2-fluoro-4-biphenyl)ethyl)-2-methylaminothiazole(113759-19-6)

Safety Data

• Hazardous Substances Data: 113759-19-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H17FN2S/c1-12(17-11-22-18(20-2)21-17)14-8-9-15(16(19)10-14)13-6-4-3-5-7-13/h3-12H,1-2H3,(H,20,21)

Upstream product

• 113743-35-4 1-chloro-3-(2-fluoro-4-biphenylyl)-2-butanone 

Downstream Products

• 145927-54-4 4-(1-(2-fluoro-4-biphenylyl)ethyl)-2-(N-t-butoxycarbonyl, N-methyl)aminothiazole 

Relevant articles and documents

Aminoazole derivatives and their production and use

A compound of the formula: STR1 wherein A is the group of the formula: wherein Ar1 is a phenyl or thienyl group which may be optionally substituted with at least one of the same or different halogen atom; Ar2 is a phenylene or thienylene group which may be optionally substituted with at least one of the same or different halogen atom; D is a divalent radical selected from the group consisting of >C=N--OR4 [wherein R4 is a hydrogen atom or lower alkyl group], >C=O, STR2 >CHOH, >NH radical, or single bond, STR3 wherein R5 is a lower alkoxy or a phenyl group which may be optionally substituted with at least one of the same or different halogen atom; E is a methine group or a nitrogen atom; F is a vinylene group or an oxygen atom, STR4 wherein R6 is a lower alkoxy group; R7 is a lower alkyl group; R8 is a benzoyl group which may be optionally substituted with at least one of the same or different halogen atom, B is a divalent azole group; R1 is a hydrogen atom or a lower alkyl group; R2 is a hydrogen atom, lower alkyl, aryl-lower alkyl, or the group of the formula: wherein R9 is a hydrogen atom, lower alkyl, halo-lower alkyl, amino-lower alkyl, aryl or aryl-lower alkyl group or the group of the formula: STR5 wherein R10 is a hydrogen atom or lower alkoxy group; R11 is a hydrogen atom, lower alkyl, lower alkenyl, lower cycloalkyl, aryl-lower alkyl, aryl or aroyl group; or the group of the formula: --NR10 R11 is a 5-, 6- or 7-membered saturated heterocyclic ring; or the group of the formula: wherein R12 is a lower alkyl or polyhalo-lower alkyl group; G is a divalent group selected from the group consisting of >C=O, >C=S, >(C=O)2 or >SO2 radical; or the group of the formula: --NR1 R2 is a 5-, 6- or 7-membered saturated heterocyclic ring: R3 is a hydrogen atom or lower alkyl group, or its acid addition salts, which is useful for immunomodulator.