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113760-29-5

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113760-29-5 Usage

Uses

A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor

Check Digit Verification of cas no

The CAS Registry Mumber 113760-29-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,7,6 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 113760-29:
(8*1)+(7*1)+(6*3)+(5*7)+(4*6)+(3*0)+(2*2)+(1*9)=105
105 % 10 = 5
So 113760-29-5 is a valid CAS Registry Number.

113760-29-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6,6-dimethyl-2-phenylimino-5,7-dihydro-1,3-benzoxathiol-4-one

1.2 Other means of identification

Product number -
Other names 6,6-dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:113760-29-5 SDS

113760-29-5Downstream Products

113760-29-5Relevant articles and documents

Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated gene transcription through inactivating inhibitory κB kinase β

Byung, Hak Kim,Roh, Eunmiri,Hwa, Young Lee,Lee, In-Jeong,Ahn, Byeongwoo,Jung, Sang-Hun,Lee, Heesoon,Han, Sang-Bae,Kim, Youngsoo

, p. 1309 - 1318 (2008)

Benzoxathiole derivatives have been used in the treatment of acne and have shown cytostatic, antipsoriatic, and antibacterial properties. However, little is known about the molecular basis for these pharmacological properties, although nuclear factor (NF)-κB activation is closely linked to inflammation and cell proliferation. Here, we demonstrate that the novel small-molecule benzoxathiole 6,6-dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo- [1,3]oxathiol-4-one (BOT-64) inhibits NF-κB activation with an IC 50 value of 1 μM by blocking inhibitory κB (IκB) kinase β (IKKβ), and suppresses NF-κB-regulated expression of inflammatory genes in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. BOT-64 inhibits IKKβ-mediated IκBα phosphorylation in LPS-activated macrophages, resulting in sequential prevention of downstream events, including proteolytic degradation of IκBα, DNA binding ability, and transcriptional activity of NF-κB. BOT-64 inhibits LPS-inducible IKKβ activity in the cells and catalytic activity of highly purified IKKβ. Moreover, the effect of BOT-64 on cell-free IKKβ was abolished by substitution of Ser-177 and Ser-181 residues in the activation loop of IKKβ to glutamic acid residues, indicating a direct interaction site of benzoxathiole. BOT-64 attenuates NF-κB-regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in LPS-activated or expression vector IKKβ-transfected macrophages. Furthermore, BOT-64 dose-dependently increases the survival rates of endotoxin LPS-shocked mice. Copyright

THE CHEMISTRY OF PHOTOLYTICALLY AND THERMALLY GENERATED α-KETOCARBENES FROM IODONIUM YLIDES OF β-DIKETONES

Hadjiarapoglou, Lazaros P.

, p. 4449 - 4450 (2007/10/02)

The reactions of Phenyliodonium dimedonate, 1, with various double bonds were investigated.The products are always heterocyclic compounds(5-member ring) in good yield.

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