1137669-98-7Relevant academic research and scientific papers
Development of a new chiral spiro oxazolinylpyridine ligand (spymox) for asymmetric catalysis
Shibatomi, Kazutaka,Muto, Tsubasa,Sumikawa, Yusuke,Narayama, Akira,Iwasa, Seiji
, p. 241 - 244 (2009)
A novel optically active 2-(oxazolinyl)pyridine ligand (Spymox) having a spiro binaphthyl backbone was synthesized from an a,a-disubstituted a-amino acid (H-Bin-OH), and successfully used in palladium-catalyzed asymmetric allylic alkylations to afford the
A chiral nitrogen - sulfur bidentate ligand and its synthetic method and application (by machine translation)
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Paragraph 0062; 0063; 0064; 0066; 0067; 0068; 0069-0071, (2018/03/26)
The invention relates to a chiral nitrogen-sulfur bidentate ligand and a synthesis method and an application thereof. The chiral nitrogen-sulfur bidentate ligand is obtained by esterifying carboxylic acid firstly and then carrying out a reaction with chiral sulfinyl amine; the ligand is combined with a transition metal palladium, symmetrical allyl acetate is used as a substrate, dimethyl malonate and dimethyl fluoromalonate are used as nucleophilic reagents, and a chiral carbon-carbon bond is successfully constructed. Compared with the prior art, the chiral nitrogen-sulfur bidentate ligand has easily obtained synthetic raw materials, and the synthetic method is simple; the prepared chiral nitrogen-sulfur bidentate ligand is N-(sulphinyl)picolinamide with optical activity is applied in construction of the chiral carbon-carbon bond catalyzed by the transition metal palladium, the reaction conditions are mild, the operation is simple, in addition, the reaction yield is also better and is generally 78%-99%, and the enantioselectivity is high and has the highest value of 93%.
