113777-23-4

Usage

Molecular Structure

A complex structure with a 1-propanone (acetone) backbone, substituted with a methoxyphenyl group and a naphthalenyl group.

Classification

A ketone derivative.

Usage

Commonly used as a building block in organic synthesis and chemical research due to its versatile reactivity and potential for creating new compounds.

Applications

May have applications in pharmaceuticals as a precursor to the synthesis of biologically active molecules.

Considerations

The specific properties and uses of this chemical may depend on its formulation and purity, and should be carefully considered before use.

Upstream product

• 4780-79-4 1-naphthalene methanol 
• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 41190-40-3 1-trifluoroacetoxynaphthalene 
• 60068-19-1 1-(trimethylsilyloxy)1-(4-methoxyphenyl)cyclopropane 

Relevant academic research and scientific papers

Method for preparing substituted ketone compound through oxidization, dehydration and alkylation of secondary alcohol

The invention discloses a method for preparing a substituted ketone compound through oxidization, dehydration and alkylation of secondary alcohol, and by means of the green synthetic method, substituted ketones are prepared from primary alcohol and the secondary alcohol through a dehydration C-alkylation-oxidization cascade reaction with the existence of alkali but without a transitional metal catalyst. According to the method, the alcohols which are low in price, easy to obtain, wide in source, stable and low in toxicity are used as alkylation reagent, common base metal inorganic base is used as an additive, methylbenzene is used as solvent, air is economical and safe oxidant, and the corresponding substituted ketone compound with secondary alcohol beta alkylated is directly synthesized through the dehydration C-alkylation-oxidization cascade reaction. The reaction method and condition are simple, no transitional metal catalyst is need, no inert gas protection is needed, the method is easy to operate, the by-product is water, compared with a precious metal catalyst, the inorganic base which is used is low in price and easy to obtain and can be removed conveniently through washing, and no heavy metal residue exists in the final product. Therefore, the method is wide in application scope and has certain research and industrial application prospect.

A chemoselective hydrogenation of the olefinic bond of α,β- unsaturated carbonyl compounds in aqueous medium under microwave irradiation

A microwave-assisted mild and ecofriendly catalytic transfer hydrogenation process was developed to reduce various α,β-unsaturated carbonyl compounds into the corresponding saturated carbonyl compounds in the presence of silica-supported palladium chloride as catalyst and a combination of MeOH/HCOOH/H2O (1:2:3) as hydrogen source within 22-55 minutes in moderate to excellent yields with 100% chemoselectivity.