1137838-12-0

Basic information

• Product Name: tert-butyl (E)-3-(3'-nitrophenyl)prop-2-en-1-yl carbonate
• Synonyms: tert-butyl (E)-3-(3'-nitrophenyl)prop-2-en-1-yl carbonate
• CAS NO: 1137838-12-0
• Molecular Weight: 279.293
• Mol File: 1137838-12-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl (E)-3-(3'-nitrophenyl)prop-2-en-1-yl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (E)-3-(3'-nitrophenyl)prop-2-en-1-yl carbonate(1137838-12-0)
• EPA Substance Registry System: tert-butyl (E)-3-(3'-nitrophenyl)prop-2-en-1-yl carbonate(1137838-12-0)

Safety Data

• Hazardous Substances Data: 1137838-12-0(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1504-64-9 (E)-3-(3-nitrophenyl)prop-2-en-1-ol 
• 645-00-1 m-iodonitrobenzene 

Relevant articles and documents

Ouabain 19-site primary hydroxyl derivative as well as preparation method and application thereof

The invention provides an ouabain 19-site primary hydroxyl derivative as well as a preparation method and application thereof. The structure of the ouabain 19-site primary hydroxyl derivative is shownas a formula I. The derivative has very low toxicity to normal cells and also has an excellent effect of inhibiting tumor cells. In addition, the derivative can effectively inhibit tumor cell migration and invasion. Therefore, the ouabain 19-site primary hydroxyl derivative has a very good application prospect in preparation of drugs for resisting tumors and inhibiting tumor invasion and/or migration.

Preparation of Boc-protected cinnamyl-type alcohols: A comparison of the Suzuki-Miyaura coupling, cross-metathesis, and Horner-Wadsworth-Emmons approaches and their merit in parallel synthesis

Three synthetic strategies for the construction of tert-butyl (E)-3-arylprop-2-en-1-ol carbonates are described. Complementary approaches employing Suzuki-Miyaura coupling and cross-metathesis reaction gave moderate yields of the title compounds in one-step, both methods are suitable for high-throughput and parallel chemistry. A detailed investigation into the Suzuki-Miyaura coupling reaction is provided along with the studies on the synthesis of pinacolyl 1-(tert-butyloxycarbonyl)propenol-3-ylboronate, the key building block. Conventional synthesis of the title compounds via the Horner-Wadsworth-Emmons reaction as a key step in a three-step-one-purification protocol was optimized and the results are compared with those of the latter reactions.