113786-33-7

Basic information

• Product Name: B 19036
• Synonyms: 10-Carboxy-3,6,9-tris(carboxymethyl)-13-phenyl-12-oxa-3,6,9-triazatridecanoic acid;4-Carboxy-5,8,11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecan-13-oic acid;B 19036
• CAS NO: 113786-33-7
• Molecular Formula: C22H31N3O11
• Molecular Weight: 513.49504
• Mol File: 113786-33-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.446
• CAS DataBase Reference: B 19036(CAS DataBase Reference)
• NIST Chemistry Reference: B 19036(113786-33-7)
• EPA Substance Registry System: B 19036(113786-33-7)

Safety Data

• Hazardous Substances Data: 113786-33-7(Hazardous Substances Data)

Usage

General Description

"B 19036" is a chemical compound that belongs to the group of pyridopyrimidine derivatives. It is a potent and selective inhibitor of the enzyme Cyclin-dependent kinase 8 (CDK8) and Cyclin-dependent kinase 19 (CDK19). These kinases are involved in the regulation of gene transcription and play a role in various cellular processes, including cell cycle progression and inflammation. In preclinical studies, "B 19036" has shown promising anti-cancer activity by inhibiting the growth and proliferation of cancer cells. It also has the potential to be used in the treatment of other diseases, such as inflammatory disorders and cardiovascular diseases. Further research and clinical trials are necessary to validate its therapeutic potential.

Upstream product

• 79-08-3 bromoacetic acid 
• 790633-35-1 N-[2-[(2-aminoethyl)amino]ethyl]-O-(phenylmethyl)serine 
• 79-11-8 chloroacetic acid 

Downstream Products

• 172504-22-2 Gd(4-carboxyl-5,6,11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecane-13-oic acid^(5-))^(2-) 
• 557762-94-4 [Eu(4-carboxy-5,8-11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecan-13-oic acid-5H)]^(2-) 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF GADOBENATE DIMEGLUMINE COMPLEX IN A SOLID FORM

The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.

Process for the preparation of contrast agents

The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.