113795-48-5

Upstream product

• 1453-06-1 4-(p-xylyl)butyric acid 
• 5394-59-2 4-(2,5-dimethylphenyl)-4-oxobutanoic acid 
• 106-42-3 para-xylene 

Downstream Products

• 113795-21-4 6-{4-[4-(2,5-Dimethyl-phenyl)-butyl]-phenoxy}-2,2-dimethyl-hexanoic acid 
• 113795-43-0 2-{4-[4-(4-Bromo-butoxy)-phenyl]-butyl}-1,4-dimethyl-benzene 
• 113795-50-9 4-(2,5-Dimethyl-phenyl)-1-(4-methoxy-phenyl)-butan-1-one 

Relevant academic research and scientific papers

Synthesis and Hypolipidemic Activity of 2-Substituted Isobutyric Acid Derivatives

A series of 2-substituted isobutyric acid derivatives have been synthesized and evaluated as hypolipidemic agents.Compounds 11 and 20 were found to decrease the level of plasma total cholesterol in experimental hyperlipidemic rats to a greater extent than clofibrate (CF) and to increase the level of plasma high-density lipoprotein cholesterol to the same extent as gemfibrozil (GF).Increase in liver weight caused by these compounds were less than those with CF and GF.

Modern Friedel-Crafts chemistry XIII. Intra- and intermolecular cyclization of some carbonyl derivatives under Friedel-Crafts conditions

Carbonyl group deactivation in the cycloalkylation of aryl haloalkyl ketones was studied.Ketones 1-5 were prepared and subjected to treatment with AlCl3, AlCl3/H2SO4 and H2SO4 catalysts.Whereas AlCl3 catalyst gave no cyclization products, the use of AlCl3/H2SO4 and H2SO4 catalysts afforded the corresponding indanones and/or tetralones (6-11).The intermediate p-methylacrylophenone (12) was also obtained in the case of ketone 2.Furthermore intermolecular cyclizations of benzene, toluene and p-xylene with 3-chloropropionyl chloride (13) and 4-chlorobutyryl chloride (14) were investigated.In the presence of AlCl3/CH3NO2 catalyst, only the corresponding aryl haloalkyl ketones (1-5) were formed whereas the use of AlCl3 catalyst gave, in addition, some cyclic ketones.However, the use of AlCl3/H2SO4 catalyst gave only the corresponding cyclic ketones (6-11).Results are discussed and mechanisms are suggested.In conclusion, carbonyl group deactivation for ring closure is demonstrated in the investigated ketones and cyclization can only effected under strenuous conditions.