1138-45-0

Basic information

• Product Name: 4(1H)-Pyridinone, 3-(phenylmethoxy)-
• CAS NO: 1138-45-0
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.225
• Mol File: 1138-45-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4(1H)-Pyridinone, 3-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyridinone, 3-(phenylmethoxy)-(1138-45-0)
• EPA Substance Registry System: 4(1H)-Pyridinone, 3-(phenylmethoxy)-(1138-45-0)

Safety Data

• Hazardous Substances Data: 1138-45-0(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 61049-67-0 3-Benzyloxy-4-pyrone 
• 1219-33-6 5-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid 
• 15771-06-9 5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one 
• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 

Relevant articles and documents

Systematic comparison of the mono-, dimethyl-and trimethyl 3-hydroxy-4(1H)-pyridones-Attempted optimization of the orally active iron chelator, deferiprone

A range of close analogues of deferiprone have been synthesised. The group includes mono-, di-and trimethyl-3-hydroxy-4(1H)-pyridones. These compounds were found to possess similar pFe3+ values to that of deferiprone, with the exception of the 2.5-dimethylated derivatives. Surprisingly the NHcontaining hydroxy-4(1H)-pyridones were found to be marginally more lipophilic than the corresponding N-Me containing analogues. This same group are also metabolised less efficiently by Phase 1 hydroxylating enzymes than the corresponding N-Me analogues. As result of this study, three compounds have been identified for further investigation centred on neutropenia and agranulocytosis.