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4(1H)-Pyridinone, 3-(phenylmethoxy)-, also known as 3-(benzyloxy)-4-pyridone or 3-benzyl-4-pyridone, is an organic compound with the chemical formula C12H11NO2. It is a derivative of pyridinone, featuring a phenylmethoxy group attached to the 3-position of the pyridinone ring. 4(1H)-Pyridinone, 3-(phenylmethoxy)- is a white crystalline solid and is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is known for its potential applications in the development of drugs targeting the central nervous system and other therapeutic areas. The compound's structure and properties make it a valuable building block in organic synthesis, particularly in the creation of more complex molecules with potential biological activity.

1138-45-0

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1138-45-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1138-45-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,3 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1138-45:
(6*1)+(5*1)+(4*3)+(3*8)+(2*4)+(1*5)=60
60 % 10 = 0
So 1138-45-0 is a valid CAS Registry Number.

1138-45-0Downstream Products

1138-45-0Relevant academic research and scientific papers

Systematic comparison of the mono-, dimethyl-and trimethyl 3-hydroxy-4(1H)-pyridones-Attempted optimization of the orally active iron chelator, deferiprone

Xie, Yuan-Yuan,Lu, Zidong,Kong, Xiao-Le,Zhou, Tao,Bansal, Sukhi,Hider, Robert

, p. 132 - 140 (2016/04/05)

A range of close analogues of deferiprone have been synthesised. The group includes mono-, di-and trimethyl-3-hydroxy-4(1H)-pyridones. These compounds were found to possess similar pFe3+ values to that of deferiprone, with the exception of the 2.5-dimethylated derivatives. Surprisingly the NHcontaining hydroxy-4(1H)-pyridones were found to be marginally more lipophilic than the corresponding N-Me containing analogues. This same group are also metabolised less efficiently by Phase 1 hydroxylating enzymes than the corresponding N-Me analogues. As result of this study, three compounds have been identified for further investigation centred on neutropenia and agranulocytosis.

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