1138337-15-1

Basic information

• Product Name: tert-butyl (1S,2R,6S)-6-[N-(3,4-dimethoxybenzyl)-N-((1R)-α-phenylethyl)-amino]-2-methyl-cyclohexane-carboxylate
• CAS NO: 1138337-15-1
• Molecular Weight: 467.649
• Mol File: 1138337-15-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (1S,2R,6S)-6-[N-(3,4-dimethoxybenzyl)-N-((1R)-α-phenylethyl)-amino]-2-methyl-cyclohexane-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (1S,2R,6S)-6-[N-(3,4-dimethoxybenzyl)-N-((1R)-α-phenylethyl)-amino]-2-methyl-cyclohexane-carboxylate(1138337-15-1)
• EPA Substance Registry System: tert-butyl (1S,2R,6S)-6-[N-(3,4-dimethoxybenzyl)-N-((1R)-α-phenylethyl)-amino]-2-methyl-cyclohexane-carboxylate(1138337-15-1)

Safety Data

• Hazardous Substances Data: 1138337-15-1(Hazardous Substances Data)

Upstream product

• 17480-69-2 (S)-N-benzyl-1-phenylethylamine 
• 5933-65-3 tert-butyl (RS)-6-methyl-cyclohex-1-ene-carboxylate 
• 134430-93-6 (R)-N-(3,4-dimethoxybenzyl)-N-(α-methylbenzyl)amine 

Relevant articles and documents

Parallel kinetic resolution of tert-butyl (RS)-6-alkyl-cyclohex-1-ene-carboxylates for the asymmetric synthesis of 6-alkyl-substituted cishexacin derivatives

Excellent levels of enantiorecognition are displayed by tert-butyl (RS)-6-n-alkyl-cyclohex-1-ene-carboxylates in mutual kinetic resolutions with lithium (RS)-N-benzyl-N-(α-methylbenzyl)amide. Therefore a 50:50 pseudoenantiomeric mixture of lithium (S)-N-benzyl-N-(α-methylbenzyl)amide and lithium (R)-N-3,4-dimethoxybenzyl-N-(α-methylbenzyl)amide allows their efficient parallel kinetic resolution, affording differentially protected 6-n-alkyl-cishexacin derivatives in high yield and >95% de. N-Debenzylation and ester hydrolysis give access to the corresponding homochiral 6-n-alkyl-substituted cishexacin derivatives.