113848-75-2Relevant academic research and scientific papers
OXIDATION OF HYDROXYAMINO- AND NITROSOPYRIMIDINES. SYNTHESIS OF 2- AND 4-NITROPYRIMIDINES
Moskalenko, G. G.,Sedova, V. F.,Mamaev, V. P.
, p. 919 - 924 (2007/10/02)
Oxidation of phenyl- and methyl-substituted 2- and 4-hydroxyamino- and -nitrosopyrimidines has given the azoxy- and nitropyrimidines, respectively.The behavior of the nitropyrimidines obtained towards reduction and nucleophilic substitution is considered.
Nucleophilic Substitutions and Eliminations of Amino Functions via Pyrimidinium Salts
Spitzner, Roland,Lesinski, Markus,Richter, Monika,Schroth, Werner
, p. 485 - 502 (2007/10/02)
Reaction of 2,4-diphenyl-1,3-thiazine-6-thione (1) with primary amines leads under ring transformation to 1-organyl-pyrimidine-6-thiones 3, which are alkylated to 1-organyl-6-methylthiopyrimidinium salts 5.The latter allow a transfer of the 1-organyl group to nucleophilic agents by departure of 2,4-diphenyl-6-methylthio-pyrimidine (8).In special cases an elimination reaction is successful.Preparative advantages and limitations are demonstrated and discussed. - Keywords: 1,3-Thiazine-6-thione; Pyrimidine-6-thiones; Pyrimidinium salts; Nucleophilic substitution; Elimination reaction
