Welcome to LookChem.com Sign In|Join Free

CAS

  • or
2-Amino-Oxazole-5-Carboxylic Acid Ethyl Ester is a versatile chemical compound utilized in the realm of organic chemistry, characterized by the presence of a carboxylic acid ester, an oxazole ring, and an amino group. These functional groups endow the compound with the capacity to engage in a variety of chemical reactions, making it a valuable reagent and building block in pharmaceutical and medicinal applications. While its potential is significant, a comprehensive understanding of its properties, toxicology, and safety measures is essential for its safe and effective use.

113853-16-0

Post Buying Request

113853-16-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

113853-16-0 Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-Oxazole-5-Carboxylic Acid Ethyl Ester serves as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Amino-Oxazole-5-Carboxylic Acid Ethyl Ester is employed as a building block for the design and synthesis of novel bioactive molecules. Its functional groups facilitate the creation of diverse chemical entities with potential medicinal properties.
Used in Organic Synthesis:
2-Amino-Oxazole-5-Carboxylic Acid Ethyl Ester is utilized as a reagent in organic synthesis, enabling the formation of complex organic molecules through various chemical reactions. Its presence of multiple functional groups makes it a versatile component in the synthesis of a wide range of organic compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 113853-16-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,8,5 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 113853-16:
(8*1)+(7*1)+(6*3)+(5*8)+(4*5)+(3*3)+(2*1)+(1*6)=110
110 % 10 = 0
So 113853-16-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O3/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3,(H2,7,8)

113853-16-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 2-aminooxazole-5-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl 2-amino-1,3-oxazole-5-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:113853-16-0 SDS

113853-16-0Relevant articles and documents

Novel CLK1 inhibitors based on N-aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands

Murár, Miroslav,Dobia?, Juraj,?ramel, Peter,Addová, Gabriela,Hanquet, Gilles,Bohá?, Andrej

supporting information, p. 754 - 761 (2016/12/16)

Background Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing in cancer. CLK family kinases are also involved in alternative splicing and RNA processing in Duchenne muscular dystrophy, Alzheimer's disease, HIV-1, and influenza virus. Small inhibitors are valuable tools for better understanding the molecular mechanisms of splicing and may serve as seeds for a novel class of therapeutics. Achievements Here we describe a discovery of four novel CLK1 inhibitors possessing N-aryloxazol-2-amine skeleton. Their activity against CLK1 (IC50: 20, 30, 40 and 80 nM) and some other CMGC kinases, predicted CLK binding poses, synthesis and physico-chemical characteristics are also stated. Additionally analysis of all PDB available CLK structures and interactions of their ligands was performed. There are only few powerful dual CLK/VEGFR inhibitors known in the literature. We proposed that our inhibitors have similar binding places and interactions in CLK1, 3 and VEGFR2 TK mostly due to the joint N-aryloxazol-2-amine pharmacophoric fragment. One of our N-aryloxazol-2-amines already proved a good activity against both VEGFR2 and CLK1 enzymes (23/80 nM, resp). We proposed that the presented class of compounds has a potential to be developed in dual VEGFR2/CLK clinical compounds with prospective synergy to treat cancer.

Synthesis of highly potent and selective hetaryl ureas as integrin αVβ3-receptor antagonists

Lange, Udo E.W.,Backfisch, Gisela,Delzer, Juergen,Geneste, Herve,Graef, Claudia,Hornberger, Wilfried,Kling, Andreas,Lauterbach, Arnulf,Subkowski, Thomas,Zechel, Christian

, p. 1379 - 1382 (2007/10/03)

Solid-phase synthesis and SAR of integrin αVβ3-receptor antagonists containing a urea moiety as non-basic guanidine mimetic are described. The most potent compounds exhibited IC50 values towards αVβ3 in the nanomolar range and high selectivity versus related integrins like αIIbβ3. For selected examples efficacy in functional cellular assays is demonstrated.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 113853-16-0