113884-65-4 Usage
Molecular weight
365.23 g/mol
Chemical structure
A nucleotide reverse transcriptase inhibitor
Mechanism of action
Inhibits the activity of the enzyme reverse transcriptase, crucial for the replication of HIV and hepatitis B virus
Prodrug
Yes, converted into its active form inside the body
Predecessor
Tenofovir disoproxil fumarate (TDF)
Dosage
Effective at lower doses than TDF
Toxicity
Lower risk of kidney and bone toxicity compared to TDF
Usage
Used to treat HIV/AIDS and chronic hepatitis B
Prescription
Typically prescribed in combination with other antiretroviral medications
Approval
Approved for the treatment of chronic hepatitis B
Check Digit Verification of cas no
The CAS Registry Mumber 113884-65-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,8,8 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 113884-65:
(8*1)+(7*1)+(6*3)+(5*8)+(4*8)+(3*4)+(2*6)+(1*5)=134
134 % 10 = 4
So 113884-65-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H11N4O5P/c13-8-6-7(9-3-10-8)12(4-11-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H,9,10,13)(H2,14,15,16)
113884-65-4Relevant articles and documents
SYNTHESIS OF N-(2-PHOSPHONYLMETHOXYETHYL) DERIVATIVES OF HETEROCYCLIC BASES
Holy, Antonin,Rosenberg, Ivan,Dvorakova, Hana
, p. 2190 - 2210 (2007/10/02)
The preparation of N-(2-phosphonylmethoxyethyl) derivatives of purine and pyrimidine bases, IV, as analogs of the antiviral 9-(2-phosphonylmethoxyethyl)adenine (PMEA,I), is described.The synthesis consists in alkylation of alkali metal salts of heterocyclic bases or their N- or O-substituted derivatives with diethyl 2-p-toluenesulfonyloxyethoxymethylphosphonate (IIa), 2-chloroethoxymethylphosphonate (IIb) or 2-bromoethoxymethylphosphonate (IIc).The obtained N-(2-diethoxyphosphonylmethoxyethyl) derivatives of heterocyclic bases (III) were treated with bromotrimethylsilane to give phosphonic acids IV.Compounds IV were prepared from pyrimidines (uracil, cytosine and their 5-methyl derivatives), purines (adenine and its N6- and C(2)-substituted derivatives, hypoxanthine, guanine, 6-hydrazinopurine and 6-methylthiopurine etc.) and their analogs (3-deazaadenine etc.).
