113903-99-4Relevant articles and documents
Amine derivatives
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Page/Page column 34, (2012/12/13)
The present invention relates to Kv1.3 potassium channel blockers of Formula (I) and their use in the treatment of autoimmune and inflammatory diseases.
AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS
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Page/Page column 56; 70, (2015/09/10)
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS
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Page/Page column 167, (2009/10/30)
The present invention relates to apoptosis signal-regulating kinase 1 ("ASK1") inhibiting compounds of the formula (I); wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.