113906-27-7 Usage
Description
2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide is a complex organic compound characterized by its unique molecular structure, which features a phenoxybenzoic acid core with a methylene-hydrazide group and a 5-methyl-2-furanyl moiety. 2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide exhibits potential biological activities and can be utilized in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide is used as a β-catenin inhibitor for disrupting the Wnt signal transduction pathway. It inhibits the interaction between β-catenin and transcription factor T-cell factor 4 (Tcf4), which can have significant implications in the study and treatment of various cancers and developmental disorders.
Used in Research Applications:
In the field of biological research, 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide is used as a Wnt signaling inhibitor to study its effects on various cellular processes. Some of these applications include:
1. As a β-catenin signaling inhibitor to study its effects on funnel cartilage differentiation in Sepia sp. embryos.
2. As a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines.
3. As a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells.
These applications highlight the compound's potential in understanding the molecular mechanisms underlying various biological processes and its possible use in developing targeted therapeutic strategies.
Biochem/physiol Actions
PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.
References
1) Trosset?et al. (2006)?Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening; Proteins,?64?60
Check Digit Verification of cas no
The CAS Registry Mumber 113906-27-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,9,0 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 113906-27:
(8*1)+(7*1)+(6*3)+(5*9)+(4*0)+(3*6)+(2*2)+(1*7)=107
107 % 10 = 7
So 113906-27-7 is a valid CAS Registry Number.
