113917-85-4Relevant academic research and scientific papers
Water clusters in supramolecular inclusion hydrates. Crystal structure of decaazatricyclo[28.2.2.2.13.16]tetratriacontane nanohydrate
Lipkowski,Simonov,Lyuboradskii,Bourosh,Popkov
, p. 806 - 813 (1999)
Inclusion compounds of solvate water molecules in a crystal matrix are investigated by X-ray diffraction analysis of a macrocyclic polyamine decaazatricyclo[28.2.2.213.16]tetratriacontane nanohydrate (I). When included in a crystal, water molecules are bonded by water-water (O-H ...O) and water-macrocycle (O-H ...N and N-H ...O) hydrogen bonds, forming a linear cluster.
In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase
Bassetto, Marcella,Leyssen, Pieter,Neyts, Johan,Yerukhimovich, Mark M.,Frick, David N.,Courtney-Smith, Matthew,Brancale, Andrea
, p. 1115 - 1131 (2016/11/09)
A structure-based virtual screening of commercial compounds was carried out on the HCV NS3 helicase structure, with the aim to identify novel inhibitors of HCV replication. Among a selection of 13 commercial structures, one compound was found to inhibit the subgenomic HCV replicon in the low micromolar range. Different series of new piperazine-based analogues were designed and synthesised, and among them, several novel structures exhibited antiviral activity in the HCV replicon assay. Some of the new compounds were also found to inhibit HCV NS3 helicase function in?vitro, and one directly bound NS3 with a dissociation constant of 570?±?270?nM.
