113924-47-3Relevant academic research and scientific papers
Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis
Nouaille, Augustin,Pannecoucke, Xavier,Poisson, Thomas,Couve-Bonnaire, Samuel
supporting information, p. 2140 - 2147 (2021/03/06)
Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).
1,1,2-Trifluoro-1,3-butadiene: A Convenient C4 Intermediate for Functionalized Monofluoroolefins
Matsuo, Noritada,Kende, Andrew S.
, p. 2304 - 2308 (2007/10/02)
The regioselective methoxybromination of 1,1,2-trifluoro-1,3-butadiene to give (Z)-4-bromo-1-methoxy-1,1,2-trifluoro-2-butene (3a) is reported.This can easily be transformed into a wide range of (Z)-2-fluoro-2-alkenoates (4a-c, 5).The reaction of benzenes
