113934-26-2

Basic information

• Product Name: 1H-1,2,3-Triazole-4-carboxaldehyde, 1-(4-nitrophenyl)-
• CAS NO: 113934-26-2
• Molecular Formula: C9H6N4O3
• Molecular Weight: 218.172
• Mol File: 113934-26-2.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 1H-1,2,3-Triazole-4-carboxaldehyde, 1-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,3-Triazole-4-carboxaldehyde, 1-(4-nitrophenyl)-(113934-26-2)
• EPA Substance Registry System: 1H-1,2,3-Triazole-4-carboxaldehyde, 1-(4-nitrophenyl)-(113934-26-2)

Safety Data

• Hazardous Substances Data: 113934-26-2(Hazardous Substances Data)

Usage

General Description

1H-1,2,3-Triazole-4-carboxaldehyde, 1-(4-nitrophenyl)- is a chemical compound with the molecular formula C9H6N4O3. It is an organic compound that contains a triazole ring and a nitrophenyl group. 1H-1,2,3-Triazole-4-carboxaldehyde, 1-(4-nitrophenyl)- is commonly used in organic synthesis and pharmaceutical research as a building block or intermediate. It can be used in the preparation of various functionalized triazole derivatives and has potential applications in medicinal chemistry and drug discovery. The compound may also have potential use as a fluorescent probe or in the development of new materials. Additionally, it has been studied for its biological and pharmacological activities, showing promising potential in various research areas.

Upstream product

• 1516-60-5 4-nitrophenyl azide 
• 107-19-7 propargyl alcohol 
• 10160-87-9 Propiolaldehyde diethyl acetal 
• 100-01-6 4-nitro-aniline 
• 133902-67-7 ethyl 1-(4-nitrophenyl)-1H-1,2,3-triazole-4-carboxylate 
• 50704-41-1 2-diazo-malonaldehyde 
• 15873-51-5 4-nitroaniline hydrochloride 
• 90886-87-6 1‐(4‐nitrophenyl)‐1H‐1,2,3‐triazole‐4‐yl‐methanol 

Downstream Products

• 1325725-20-9 1-(4-nitrophenyl)-4-vinyl-1H-1,2,3-triazole 
• 34296-51-0 1-phenyl-1,2,3-triazole-4-carbaldehyde 
• 100-01-6 4-nitro-aniline 
• 113934-25-1 1-(4-methylphenyl)-1H-1,2,3-triazole-4-carboxaldehyde 
• 1325724-91-1 1-(2-methylphenyl)-1H-1,2,3-triazole-4-carbaldehyde 
• 944905-72-0 1-(m-tolyl)-4,5-dihydro-1H-1,2,3-triazole-4-carbaldehyde 
• 578703-90-9 1-(4-fluorophenyl)-4,5-dihydro-1H-1,2,3-triazole-4-carbaldehyde 
• 124940-34-7 1-(phenylmethyl)-1H-1,2,3-triazole-4-carboxaldehyde 

Relevant articles and documents

[HDBU][HSO4]-catalyzed facile synthesis of new 1,2,3-triazole-tethered 2,3-dihydroquinazolin-4[1H]-one derivatives and their DPPH radical scavenging activity

A simple and efficient protocol has been developed for the synthesis of new1,2,3-triazole-2,3-dihydroquinazolin-4[1H]-one (DHQ) conjugates(6a?j) via ultrasound-assisted, solvent-free ionic liquid [HDBU][HSO4]-catalyzed reaction in good to excellent yields. This non-conventional, ultrasound-assisted route has taken the reactions over the conventional reflux method to provide good to excellent yields of the corresponding products (6a?j) in a very short time. In addition, mild reaction conditions, tolerance to functionalized substrates, ease of product isolation, prevention of its over oxidation and reusability of catalyst [HDBU][HSO4] are some key striking features of the methodology. The newly synthesized derivatives (6a?j) were screened for antioxidant activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) assay and are found to be a potent scavenger. The compounds 6b, 6c, 6d, 6e and 6i showed significant antioxidant activity. Molecular docking studies showed significant binding affinity in the active site of myeloperoxidase (MPO) enzyme and hence scavenged by inhibition of MPO. In silico ADMET and pharmacokinetic studies of the conjugates are very promising; a cumulative body of evidence suggests their medicinal value as a potential orally active drug candidate. Graphical abstract: [Figure not available: see fulltext.]

[Et3NH][HSO4] catalyzed solvent-free synthesis of new 1,2,3-triazolidene-indolinone derivatives

A series of new 1,2,3-triazolidene-indolinone derivatives (17a-j) were designed and synthesized via [Et3NH] [HSO4] catalyzed solvent-free approach. The synthesis strongly relied on Knoevenagel condensation of 1,4-disubstituted 1,2,3-

Synthesis, characterization and photodynamic activity against bladder cancer cells of novel triazole-porphyrin derivatives

Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of