113934-34-2

Upstream product

• 31709-47-4 3-(4-methoxyphenyl)isoxazol-5(4H)-one 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 418783-97-8 C₁₃H₁₃NO₄ 

Relevant academic research and scientific papers

Rhodium(iii)-catalysed decarboxylative C-H functionalization of isoxazoles with alkenes and sulfoxonium ylides

Decarboxylative C-H functionalization of isoxazoles with electron-deficient alkenes and sulfoxonium ylides at the C5 position was achieved in the presence of rhodium(iii) catalysts to give the corresponding alkenylation and acylmethylation products, respe

Rhodium(iii)-catalysed carboxylate-directed C-H functionalizations of isoxazoles with alkynes

An efficient oxidative [4+2] annulation of isoxazolyl-4-carboxylic acids with internal alkynes proceeded in the presence of the [Cp?RhCl2]2 catalyst. Oxidants controlled the formation of pyranoisoxazolones and isoquinolines. A decarb

A 3 - substituted - 4 - isoxazole carboxylic acid synthesizing method

The invention relates to a synthesis method of high-purity and high-regioselectivity 3-substituted-4-isoxazole carboxylic acid. The method has the advantages of simplicity and easiness in operation, mild reaction and high yield and can solve the technical problems of harsh reaction conditions, generation of isomers, difficulty in separation, low total yield and difficulty in large-scale production of the existing preparation method. The preparation steps are as follows: taking 3-substituted-3-oxopropionate (I) as a starting raw material, and performing cyclization with hydroxylamine hydrochloride and an alkali in water to prepare 3-substituted-4-isoxazole-5-ketone (II); performing acetalization on the compound (II) and N, N-dimethylformamide dimethyl acetal to prepare 4-dimethylaminomethylene-3-substituted-4-hydrogen-isoxazol-5-ketone (III); performing ring opening by hydrolysis of lactone on the compound (III) in alkaline conditions and re-closing a ring; and acidifying to obtain the 3-substituted-4-isoxazole carboxylic acid. The method for the 3-substituted-4-isoxazole carboxylic acid, provided by the invention, is used for development and large-scale preparation.

SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF 11BETA-HSD-1

Compounds of formula I and IV are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorder: wherein the variables A-B, R1, R2, m, and Q are described herein.